407625
STAT3 Inhibitor XVI
The STAT3 Inhibitor XVI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Cancer applications.
别名:
STAT3 Inhibitor XVI, IL-6 Inhibitor
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关于此项目
经验公式（希尔记法）:
C21H22N2O3S3
化学文摘社编号:
分子量:
446.61
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
STAT3 Inhibitor XVI, The STAT3 Inhibitor XVI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Cancer applications.
InChI
1S/C21H22N2O3S3/c1-15-6-8-16(9-7-15)20-19(29(25,26)23-10-2-3-11-23)13-18(28-20)21(24)22-14-17-5-4-12-27-17/h4-9,12-13H,2-3,10-11,14H2,1H3,(H,22,24)
InChI key
NVANVFNPZWSWRM-UHFFFAOYSA-N
SMILES string
O=C(NCC1=CC=CS1)C2=CC(S(N3CCCC3)(=O)=O)=C(C4=CC=C(C)C=C4)S2
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
gray
solubility
DMSO: 50 mg/mL, light pink-purple
shipped in
ambient
storage temp.
2-8°C
Quality Level
Disclaimer
Toxicity: Regulatory Review (Z)
General description
A cell-permeable, arylsulphonamidyl thiophene amide that is shown to reduce IL-6-induced STAT3 transcriptional activity (EC50 = 15 µM) in a luciferase reporter assay, in HeLa cells. It selectively inhibits STAT3, but not STAT1, phosphorylation following IL-6 stimulation in both HeLa and MDA-MB-231 breast cancer cells at concentrations of 10-30 µ:M and 30-100 µM, respectively. Following IL-6 stimulation, it suppresses the cell viability of STAT3-dependent cancer cells by 40% compared with that of STAT3-null cancer cells at the low micromolar level.
Other Notes
Zinzalla, G., et al. 2010. Bioorg Med Chem Lett20, 7029.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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