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质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
gray
溶解性
DMSO: 50 mg/mL, light pink-purple
运输
ambient
储存温度
2-8°C
SMILES字符串
O=C(NCC1=CC=CS1)C2=CC(S(N3CCCC3)(=O)=O)=C(C4=CC=C(C)C=C4)S2
InChI
1S/C21H22N2O3S3/c1-15-6-8-16(9-7-15)20-19(29(25,26)23-10-2-3-11-23)13-18(28-20)21(24)22-14-17-5-4-12-27-17/h4-9,12-13H,2-3,10-11,14H2,1H3,(H,22,24)
InChI key
NVANVFNPZWSWRM-UHFFFAOYSA-N
一般描述
A cell-permeable, arylsulphonamidyl thiophene amide that is shown to reduce IL-6-induced STAT3 transcriptional activity (EC50 = 15 µM) in a luciferase reporter assay, in HeLa cells. It selectively inhibits STAT3, but not STAT1, phosphorylation following IL-6 stimulation in both HeLa and MDA-MB-231 breast cancer cells at concentrations of 10-30 µ:M and 30-100 µM, respectively. Following IL-6 stimulation, it suppresses the cell viability of STAT3-dependent cancer cells by 40% compared with that of STAT3-null cancer cells at the low micromolar level.
包装
Packaged under inert gas
警告
Toxicity: Regulatory Review (Z)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Zinzalla, G., et al. 2010. Bioorg Med Chem Lett20, 7029.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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