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Merck
CN
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主要文件

407331

Sigma-Aldrich

ILK抑制剂，Cpd 22

The ILK inhibitor, Cpd 22 controls the biological activity of ILK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

别名:

ILK抑制剂，Cpd 22

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About This Item

经验公式（希尔记法）:
C30H30F3N5O
分子量:
533.59
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

方案

≥94% (HPLC)

表单

powder

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

off-white

溶解性

DMSO: 100 mg/mL

运输

ambient

储存温度

2-8°C

一般描述

一种细胞可渗透的三取代吡唑化合物，可作为有效和特异性整联蛋白连接激酶（ILK）抑制剂（IC50=600 nM）。显示对前列腺和乳腺癌细胞系具有高体外抗增殖效价（IC50 = 1 - 2.5 µM），同时保留正常上皮细胞。 其对癌症细胞的效应已归因于自噬和诱导的凋亡。抑制ILK介导的Ser473位点Akt磷酸化，从而下调下游靶标，如GSK-3b和肌球蛋白轻链。还引起转录因子Y-Box结合蛋白1（YB-1）的转录抑制。在小鼠模型中表现出最小毒性。
一种细胞可渗透的三取代吡唑化合物，可作为有效和特异性整联蛋白连接激酶（ILK）抑制剂（IC50=600 nM）。显示对前列腺和乳腺癌细胞系具有高体外抗增殖效价（IC50 = 1 - 2.5 M），同时保留正常上皮细胞。 其对癌症细胞的效应已归因于自噬和诱导的凋亡。抑制ILK介导的Ser473位点Akt磷酸化，从而下调下游靶标，如GSK-3b和肌球蛋白轻链。还引起转录因子Y-Box结合蛋白1（YB-1）的转录抑制。在小鼠模型中表现出最小毒性。

包装

用惰性气体包装

警告

毒性：标准处理（A）

重悬

复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

其他说明

Lee, S., et al. 2011.J. Med. Chem.54, 6364

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Sacha Robert et al.
International journal of molecular sciences, 22(19) (2021-10-14)
Differentiation of pluripotent stem cells to cardiomyocytes is influenced by culture conditions including the extracellular matrices or similar synthetic scaffolds on which they are grown. However, the molecular mechanisms that link the scaffold with differentiation outcomes are not fully known.
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Biological psychiatry, 86(5), 377-387 (2019-05-28)
Cue-induced relapse to drug use is a primary symptom of cocaine addiction. Cue-induced transient excitatory synaptic potentiation (t-SP) induced in the nucleus accumbens mediates cued cocaine seeking in rat models of relapse. Cue-induced t-SP depends on extracellular signaling by matrix
Seda Mehtap Sarı Kılıçaslan et al.
Iranian journal of basic medical sciences, 24(11), 1500-1508 (2022-03-24)
This study examines the impact of integrin-linked kinase (ILK), protein kinase B (AKT), glycogen synthase kinase-3β (GSK-3β), and β-catenin signal molecules in SKOV-3 ovarian cancer cells adhered to fibronectin. Expression levels of α4, αv, β1, and β6 integrin subunits known
Jingying Chen et al.
Nature communications, 15(1), 5986-5986 (2024-07-17)
In zebrafish, brain lymphatic endothelial cells (BLECs) are essential for meningeal angiogenesis and cerebrovascular regeneration. Although epidermal growth factor-like domain 7 (Egfl7) has been reported to act as a pro-angiogenic factor, its roles in lymphangiogenesis remain unclear. Here, we show
Esak Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 120(41), e2308941120-e2308941120 (2023-10-02)
Impaired lymphatic drainage and lymphedema are major morbidities whose mechanisms have remained obscure. To study lymphatic drainage and its impairment, we engineered a microfluidic culture model of lymphatic vessels draining interstitial fluid. This lymphatic drainage-on-chip revealed that inflammatory cytokines that
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