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质量水平
检测方案
≥94% (HPLC)
形式
powder
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
DMSO: 100 mg/mL
运输
ambient
储存温度
2-8°C
一般描述
一种细胞可渗透的三取代吡唑化合物,可作为有效和特异性整联蛋白连接激酶(ILK)抑制剂(IC50=600 nM)。显示对前列腺和乳腺癌细胞系具有高体外抗增殖效价(IC50 = 1 - 2.5 µM),同时保留正常上皮细胞。 其对癌症细胞的效应已归因于自噬和诱导的凋亡。抑制ILK介导的Ser473位点Akt磷酸化,从而下调下游靶标,如GSK-3b和肌球蛋白轻链。还引起转录因子Y-Box结合蛋白1(YB-1)的转录抑制。在小鼠模型中表现出最小毒性。
一种细胞可渗透的三取代吡唑化合物,可作为有效和特异性整联蛋白连接激酶(ILK)抑制剂(IC50=600 nM)。显示对前列腺和乳腺癌细胞系具有高体外抗增殖效价(IC50 = 1 - 2.5 M),同时保留正常上皮细胞。 其对癌症细胞的效应已归因于自噬和诱导的凋亡。抑制ILK介导的Ser473位点Akt磷酸化,从而下调下游靶标,如GSK-3b和肌球蛋白轻链。还引起转录因子Y-Box结合蛋白1(YB-1)的转录抑制。在小鼠模型中表现出最小毒性。
包装
用惰性气体包装
警告
毒性:标准处理(A)
重悬
复溶后,等分并冷冻保存(-20°C)。储备溶液在-20°C下可稳定保存至多3个月。
其他说明
Lee, S., et al. 2011.J. Med. Chem.54, 6364
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Differentiation of pluripotent stem cells to cardiomyocytes is influenced by culture conditions including the extracellular matrices or similar synthetic scaffolds on which they are grown. However, the molecular mechanisms that link the scaffold with differentiation outcomes are not fully known.
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This study examines the impact of integrin-linked kinase (ILK), protein kinase B (AKT), glycogen synthase kinase-3β (GSK-3β), and β-catenin signal molecules in SKOV-3 ovarian cancer cells adhered to fibronectin. Expression levels of α4, αv, β1, and β6 integrin subunits known
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Cue-induced relapse to drug use is a primary symptom of cocaine addiction. Cue-induced transient excitatory synaptic potentiation (t-SP) induced in the nucleus accumbens mediates cued cocaine seeking in rat models of relapse. Cue-induced t-SP depends on extracellular signaling by matrix
Journal of immunology (Baltimore, Md. : 1950), 201(8), 2369-2376 (2018-09-12)
Cryptococcus neoformans is a fungal pathogen that causes fatal meningitis and pneumonia. During host defense to Cryptococcus, NK cells directly recognize and kill C. neoformans using cytolytic degranulation analogous to killing of tumor cells. This fungal killing requires independent activation
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The crosstalk between tumor cells and the adjacent normal epithelium contributes to cancer progression, but its regulators have remained elusive. Here, we show that breast cancer cells maintained in hypoxia release small extracellular vesicles (sEVs) that activate mitochondrial dynamics, stimulate
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