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质量水平
方案
≥95% (HPLC)
表单
liquid
效能
18 nM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
clear pale yellow
运输
wet ice
储存温度
2-8°C
一般描述
IKK-2 Inhibitor IV (Cat. No. 401481) supplied in DMSO. A cell-permeable and potent inhibitor of IKK-2 (IC50 = 18 nM) that exhibits selectivity over IKK-1, JNK, and p38 MAPK. Inhibits TNF-α production in human monocytes (IC50 in the range of 0.15-2.5 µM) and blocks IL-8 and IL-6 production by synovial fibroblasts (IC50 = 100 nM). Shown to reduce paw oedema in rat arthritis model (~100% inhibition at a dose of 30 mg/kg).
生化/生理作用
Cell permeable: yes
Product competes with ATP.
Reversible: yes
包装
Packaged under inert gas
警告
Toxicity: Irritant (B)
外形
A 10 mM (500 µg/179 µl) solution of IKK-2 Inhibitor IV (Cat. No. 401481) in DMSO.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
闪点(°C)
87 °C - closed cup - (Dimethylsulfoxide)
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