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一般描述
An ureido-thiophenecarboxamide compound that acts as a potent, cell-permeable, reversible, and ATP-competitive inhibitor of IKK-2 (IC50 = 13 nM).
生化/生理作用
IKK-2
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
储存分类代码
10-13 - German Storage Class 10 to 13
Andrew Baxter et al.
Bioorganic & medicinal chemistry letters, 14(11), 2817-2822 (2004-05-06)
A hit-to-lead optimisation programme was carried out on the thiophenecarboxamide high throughput screening hits 1 and 2 resulting in the discovery of the potent and orally bioavailable IKK-2 inhibitor 22.
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