推荐产品
产品名称
缺氧诱导因子羟化酶抑制剂，DMOG, The HIF-Hydroxylase Inhibitor, DMOG, also referenced under CAS 89464-63-1, controls the biological activity of HIF-Hydroxylase. This small molecule/inhibitor is primarily used for Cell Structure applications.
质量水平
方案
≥98% (HPLC)
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
颜色
pink-white to peach-white
溶解性
DMSO: 50 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
N(CC(=O)OC)C(=O)C(=O)OC
InChI
1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
InChI key
BNJOZDZCRHCODO-UHFFFAOYSA-N
一般描述
一种可渗透细胞的2-OG（2-氧戊二酸酯）类似物，有望作为所有2-OG依赖性双加氧酶的竞争性抑制剂。通过抑制HIF-PH-（HIF-α-脯氨酰羟化酶）催化的ODD（氧依赖性降解域）脯氨酰羟化（分别为HIF-1α和HIF-2α中的Pro564和Pro530）和天冬氨酰/天冬氨酰β羟化酶催化的CAD Asp羟基化（分别为HIF-1α和HIF-2α中的Asn803和Asn851），有效上调常氧HIF-α转录活性（培养物中的有效浓度=1 mM），阻断pVHL（von Hippel-Lindau）泛素连接酶复合物介导的HIF-α降解，同时促进HIF CAD（COOH末端激活域）p300/CBP关联性。还证明，DMOG可增强鼠体内缺血模型肌肉组织中动脉结扎诱导的HIF-1α和FLK的上调（在11天内分别上调100%和40%；8 mg/0.5 ml/动物/腹膜内；q.o.d.）。
警告
毒性：标准处理（A）
重悬
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他说明
Pollard, P.J., et al. 2008.Biochem.J.416, 387.
Chen, H., et al. 2006.Cancer Res.66, 9009.
Milkiewicz, M., et al. 2004.J. Physiol.560, 21.
Lando, D., et al. 2002.Science295, 858.
Jaakkola, P., et al. 2001.Science292, 468.
Chen, H., et al. 2006.Cancer Res.66, 9009.
Milkiewicz, M., et al. 2004.J. Physiol.560, 21.
Lando, D., et al. 2002.Science295, 858.
Jaakkola, P., et al. 2001.Science292, 468.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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