400087
HIF-2α翻译抑制剂
The HIF-2α Translation Inhibitor, also referenced under CAS 882268-69-1, controls the biological activity of HIF-2α. This small molecule/inhibitor is primarily used for Cell Structure applications.
别名:
HIF-2α翻译抑制剂, 缺氧诱导因子-2α翻译抑制剂，甲基-3-（2-（氰基（甲磺酰基）亚甲基）肼基）噻吩-2-羧酸盐，HIF抑制剂II
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About This Item
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质量水平
方案
≥95% (sum of two isomers)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
amber
溶解性
DMSO: 5 mg/mL
运输
ambient
储存温度
2-8°C
一般描述
通过增强IRP1（铁调节蛋白1）与HIF-2α mRNA 5′ UTR处的IRE（铁反应元件）区域的结合来抑制细胞HIF-2α信息翻译的细胞渗透性噻吩腙化合物，否则对HIF-2α mRNA的转录或HIF-2α mRNA和蛋白的稳定性没有影响。已显示可降低仅表达2α种低氧诱导因子同工型的786-O细胞（终浓度为5-10 µM）中HIF-2α和HIF-2α靶基因（包括Glut-1，IGFBP3和VEGF）的细胞蛋白水平。
包装
用惰性气体包装
警告
毒性：标准处理（A）
重悬
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多6个月。
其他说明
Zimmer, M., et al. 2008.Mol.Cell32, 838.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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