400086
HIF Inhibitor VI
The HIF-1 Inhibitor, NSC-134754 controls the biological activity of HIF-1. This small molecule/inhibitor is primarily used for Cell Structure applications.
别名:
HIF Inhibitor VI, NSC-134754
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所有图片(1)
About This Item
经验公式（希尔记法）:
C27H34N2O2
分子量:
418.57
UNSPSC代码:
12352200
NACRES:
NA.77
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质量水平
方案
≥90% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
brown
溶解性
DMSO: 50 mg/mL
运输
ambient
储存温度
2-8°C
一般描述
A cell-permeable emetan derivative that selectively reduces HIF-1 activity by 73% in a luciferase reporter assay, and blocks HIF-1α protein induction in response to DFX, hypoxia, and IGF-1 in U2OS-HRE-luc cells at 10 µM, without significantly inhibiting cell growth. Furthermore, it is shown to completely block HIF-1α induced by IGF-1 in HCT116 human colon carcinoma cells.
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
其他说明
Chau, N.M., et al. 2005. Cancer Res.65, 4918.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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