400076-M
Hypericin
Polycyclic dione that has anti-retroviral activity.
别名:
Hypericin, Casein Kinase II Inhibitor XI
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关于此项目
经验公式（希尔记法）:
C30H16O8
化学文摘社编号:
分子量:
504.44
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.77
产品名称
Hypericin, Polycyclic dione that has anti-retroviral activity.
SMILES string
Oc1c2c3c4c5c6c2c(cc(c6C(=O)c7c5c(c8c4c(c(cc8C)O)C(=O)c3c(c1)O)c(cc7O)C)O)O
InChI
1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3
InChI key
BTXNYTINYBABQR-UHFFFAOYSA-N
description
Merck USA index - 14, 4863
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
black
solubility
ethanol: 1 mg/mL
methanol: 1 mg/mL
DMSO: 10 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Target IC50: 3.3 µM, 6 nM, 4 nM, 20-29 nM , 35 nM, against protein kinase C, casein kinase II, MAP kinase, the protein tyrosine activities of the insulin receptor, and the epidermal growth factor receptor, respectively
Primary Target
PKC
PKC
Disclaimer
Toxicity: Harmful (C)
General description
Polycyclic dione that has anti-retroviral activity. Inhibits protein kinase C (IC50 = 3.3 µM). Also known to inhibit the protein tyrosine kinase activities of the insulin receptor (IC50 = 20-29 nM), the epidermal growth factor receptor (IC50 = 35 nM), casein kinase II (IC50 = 6 nM), and MAP kinase (IC50 = 4 nM). Useful probe for PKC due to its bright red fluorescence emission and photostability. Also see Pseudohypericin (Cat. No. 539590).
Other Notes
Zhang, W., et al. 1997. Cancer Lett.120, 31.
Agostinis, P., et al. 1995. Biochem. Pharmacol.49, 1615.
Frew, T., et al. 1994. Anticancer Res.14, 2425.
Barnard, D.L., et al. 1992. Antiviral Res.17, 63.
Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun.165, 1207.
Agostinis, P., et al. 1995. Biochem. Pharmacol.49, 1615.
Frew, T., et al. 1994. Anticancer Res.14, 2425.
Barnard, D.L., et al. 1992. Antiviral Res.17, 63.
Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun.165, 1207.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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