Caspase-1 Inhibitor IV

A highly selective, competitive, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.

Highly selective, competitive and irreversible inhibitor of caspase-1 and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles, such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.

Cell permeable: yes

Primary Target
caspase-1

Product does not compete with ATP.

Reversible: no

Toxicity: Standard Handling (A)

Ac-Tyr-Val-Ala-Asp-AOM (AOM = 2,6-dimethylbenzoyloxymethyl ketone)

Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.

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