385920
HSP90 Inhibitor, CCT018159
The HSP90 Inhibitor, CCT018159, also referenced under CAS 171009-07-7, controls the biological activity of HSP90.
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所有图片(1)
别名:
HSP90 Inhibitor, CCT018159, 4-(4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylresorcinol
经验公式（希尔记法）:
C20H20N2O4
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质量水平
检测方案
≥98% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
water: 1.7 mg/mL
DMSO: 35 mg/mL
ethanol: 35 mg/mL
运输
ambient
储存温度
−20°C
InChI
1S/C20H20N2O4/c1-3-12-8-14(16(24)10-15(12)23)20-19(11(2)21-22-20)13-4-5-17-18(9-13)26-7-6-25-17/h4-5,8-10,23-24H,3,6-7H2,1-2H3,(H,21,22)
InChI key
OWPMENVYXDJDOW-UHFFFAOYSA-N
一般描述
A cell-permeable pyrazoloresorcinol compound that inhibits HSP90 ATPase activity (IC50 = 3.2 µM and 6.6 µM against human HSP90β and yeast HSP90, respectively) by targeting the enzyme′s N-terminal ATP binding site. It exhibits no detectable effects against human Hsp70 or topoisomerase II even at concentrations as high as 100 µM and inhibits a panel of 20 commonly studied kinases only at much higher concentrations. Unlike 17-AAG (Cat. No. 100068), the antitumor activity of CCT018159 is not affected by the expression of NQ01/DT-diaphorase or P-glycoprotein.
包装
Packaged under inert gas
警告
Toxicity: Irritant (B)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solution are stable for up to 3 months at -20°C.
其他说明
Hardcastle, A., et al. 2007. Mol. Cancer Ther.6, 1112.
Sharp, S.Y., et al. 2007. Cancer Res.67, 2206.
Smith, N.F., et al. 2006. Mol. Cancer Ther.5, 1628.
Dymock, B.W., et al. 2005. J. Med. Chem.48, 4212.
Cheung, K.M., et al. 2005. Bioorg. Med. Chem. Lett.15, 3338.
Sharp, S.Y., et al. 2007. Cancer Res.67, 2206.
Smith, N.F., et al. 2006. Mol. Cancer Ther.5, 1628.
Dymock, B.W., et al. 2005. J. Med. Chem.48, 4212.
Cheung, K.M., et al. 2005. Bioorg. Med. Chem. Lett.15, 3338.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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