382177
HDAC Inhibitor XIX, Compound 2
The HDAC Inhibitor XIX, Compound 2, also referenced under CAS 6953-61-3, controls the biological activity of HDAC. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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所有图片(1)
别名:
HDAC Inhibitor XIX, Compound 2, 1-Naphthohydroxamic Acid, N-Hydroxynaphthalene-1-carboxamide, Histone Deacetylase Inhibitor XIX
经验公式（希尔记法）:
C11H9NO2
推荐产品
质量水平
检测方案
≥97% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 50 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)
InChI key
JRZGPWOEHDOVMC-UHFFFAOYSA-N
一般描述
A cell-permeable aryl-hydroxamate compound that selectively inhibits the activity of HDAC8 (IC50 = 14 µM) over class I HDAC1 and class II HDAC6 (IC50 >100 µM) without affecting the overall H4 acetylation level in BE(2)-C cultures even at concentrations as high as 20 µM. HDAC8 downregulation by either Compound 2 (10 to 40 µM) or siRNA in neuroblastoma cultures is reported to result in growth inhibition accompanied by neurite-like morphological changes. Compound 2 effectively enhances tubulin acetylation in both HeLa and HEK 293 cultures, indicating that alternative cellular enzyme(s) other than HDAC6 can be targeted for regulating tubulin acetylation.
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Oehme, I., et al. 2009. Expert Opin. Investig. Drugs18, 1605.
Oehme, I., et al. 2009. Clin. Cancer Res.15, 91.
KrennHrubec, K., et al. 2007. Bioorg. Med. Chem. Lett.17, 2874.
Oehme, I., et al. 2009. Clin. Cancer Res.15, 91.
KrennHrubec, K., et al. 2007. Bioorg. Med. Chem. Lett.17, 2874.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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