重组
expressed in E. coli
质量水平
形式
liquid
比活
≥10,000 units/mL
≥5,000 units/mg protein
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
技术
molecular cloning: suitable
异质活性
Nuclease-free
运输
wet ice
储存温度
−20°C
一般描述
在大肠埃希菌中表达的重组HIV逆转录酶。催化DNA和RNA模板上容易出错的合成。为评估抗病毒药物提供了一个极好的靶标。
应用
大肠杆菌来源重组HIV 逆转录酶可用作逆转录酶活性测定标准品。
包装
请参考特定浓度批号的标签。
警告
毒性：标准处理（A）
单位定义
一个单位定义为在37°C，pH 8.3下20分钟内将1.0 nmol标记的dTTP掺入酸不溶性物质中的酶量。
外形
在10 mM磷酸钾，1 mM DTT，20%甘油（pH 7.4）中。
重悬
初次融化后，等分并冷冻（-20°C）。
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Geraldine Vilmen et al.
mBio, e0275221-e0275221 (2022-01-12)
Infection of rhesus macaques with simian-human immunodeficiency viruses (SHIVs) is the preferred model system for vaccine development because SHIVs encode human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Envs)-a key target of HIV-1 neutralizing antibodies. Since the goal of vaccines
Conformation of HIV-1 Envelope governs rhesus CD4 usage and simian-human immunodeficiency virus replication
Vilmen G, et al.
mBio, 13(1), e02752-e02721 (2022)
Identification of an antiretroviral small molecule that appears to be a host-targeting inhibitor of HIV-1 assembly
Reed JC, et al.
Journal of Virology, 95(3), 10-1128 (2021)
Bo Meng et al.
Cell reports, 35(13), 109292-109292 (2021-06-25)
We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase binding affinity to the ACE2 receptor and confer
Jonathan C Reed et al.
Journal of virology, 95(3) (2020-11-06)
Given the projected increase in multidrug-resistant HIV-1, there is an urgent need for development of antiretrovirals that act on virus life cycle stages not targeted by drugs currently in use. Host-targeting compounds are of particular interest because they can offer
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