376816
Hexokinase II VDAC Binding Domain Peptide, Cell-Permeable
A cell-permeable peptide analog of Hexokinase II VDAC binding domain peptide.
别名:
Hexokinase II VDAC Binding Domain Peptide, Cell-Permeable, HXK2VBD-cpm, H- RQIKIWFQNRRMKWKK-MIASHLLAYFFTELN-NH₂
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所有图片(1)
About This Item
经验公式（希尔记法）:
C188H291N53O40S2
分子量:
3997.78
UNSPSC代码:
12352202
NACRES:
NA.77
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质量水平
方案
≥95% (HPLC)
表单
lyophilized solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
white
溶解性
water: 1 mg/mL
运输
wet ice
储存温度
−20°C
一般描述
A cell-permeable peptide analog of Hexokinase II VDAC binding domain peptide (Cat. No. 376815). The internalization domain of the Antennapedia homeoprotein is fused to the methionine amino terminal. Shown to completely detach and translocate HXK2 from mitochondria to the cytosol in HeLa cells at 100 µM. Does not induce Bax translocation or cytochrome c release when used alone. However, it markedly sensitizes cells to cytochrome c release and to the induction of apoptosis when used in combination with a Bax-dependent apoptosis inducer, Indomethacin (Cat. No. 405268).
生化/生理作用
Cell permeable: yes
Primary Target
Detach and translocate HXK2 from mitochondria to the cytosol
Detach and translocate HXK2 from mitochondria to the cytosol
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
序列
H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Met-Ile-Ala-Ser-His-Leu-Leu-Ala-Tyr-Phe-Phe-Thr-Glu-Leu-Asn-NH₂
其他说明
Pastorino, J.G., et al. 2002. J. Biol. Chem.277, 7610.
Holinger, E.P., et al. 1999. J. Biol. Chem.274, 13298.
Sui, D., and Wilson, J.E. 1997. Arch. Biochem. Biophys.345, 111.
Holinger, E.P., et al. 1999. J. Biol. Chem.274, 13298.
Sui, D., and Wilson, J.E. 1997. Arch. Biochem. Biophys.345, 111.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Jia Sun et al.
Redox biology, 39, 101811-101811 (2020-12-29)
Vascular complications of diabetes are a serious challenge in clinical practice, and effective treatments are an unmet clinical need. Acidic fibroblast growth factor (aFGF) has potent anti-oxidative properties and therefore has become a research focus for the treatment of diabetic
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