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Merck
CN
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主要文件

372770

Sigma-Aldrich

HBDDE

A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKC&alpha and PKCγ over PKCδ, βI, and βII isozymes in in vitro assays.

别名:

HBDDE, 2,2ʹ,3,3ʹ,4,4ʹ-Hexahydroxy-1,1ʹ-biphenyl-6,6ʹ-dimethanol Dimethyl Ether

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About This Item

经验公式（希尔记法）:
C16H18O8
CAS号:
154675-18-0
分子量:
338.31
MDL编号:
MFCD00925616
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

方案

≥95% (TLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

orange

溶解性

ethanol: 1 mg/mL
warm water: 1 mg/mL
DMSO: 5 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

O(Cc1c(c(c(c(c1)O)O)O)c2c(c(c(cc2COC)O)O)O)C

InChI

1S/C16H18O8/c1-23-5-7-3-9(17)13(19)15(21)11(7)12-8(6-24-2)4-10(18)14(20)16(12)22/h3-4,17-22H,5-6H2,1-2H3

InChI key

NEBCAMAQXZIVRE-UHFFFAOYSA-N

一般描述

A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKCα (IC50 = 43 µM) and PKCγ (IC50 = 50 µM) over PKCδ, βI, and βII isozymes in in vitro assays. Reported to induce apoptosis in rodent cerebellar granule neurons.
Protein kinase C (PKC) inhibitor. Selectively inhibits PKCα (IC50 = 43 µM) and PKCγ (IC50 = 50 µM) over PKCδ, βI and βII isozymes.

生化/生理作用

Cell permeable: yes
Primary Target
PKCα
Product does not compete with ATP.
Reversible: no
Target IC50: 43 µM against PKCα

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Mathur, A., and Vallano, M.L. 2000. Biochem. Pharmacol.60, 809.
Kashiwada, Y., et al. 1994. J. Med. Chem. 37, 195.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Curtis B Read et al.
mBio, 15(4), e0029924-e0029924 (2024-02-28)
Many intracellular pathogens structurally disrupt the Golgi apparatus as an evolutionarily conserved promicrobial strategy. Yet, the host factors and signaling processes involved are often poorly understood, particularly for Anaplasma phagocytophilum, the agent of human granulocytic anaplasmosis. We found that A.

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