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Merck
CN
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主要文件

371725

Sigma-Aldrich

GPR43（FFA2）激动剂

The GPR43 (FFA2) Agonist controls the biological activity of GPR43. This small molecule/inhibitor is primarily used for Biochemicals applications.

别名:

GPR43（FFA2）激动剂, （S）-2-（4-氯苯基）-3，3-二甲基-N-（5-苯基噻唑-2-基）丁酰胺

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About This Item

经验公式（希尔记法）:
C21H21ClN2OS
CAS号:
1208552-99-1
分子量:
384.92
MDL编号:
MFCD00149550
UNSPSC代码:
51111800
NACRES:
NA.77

质量水平

100

方案

>98% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

white

溶解性

DMSO: 50 mg/mL

运输

ambient

储存温度

2-8°C

一般描述

一种苯乙酰胺化合物，可作为FFA2的变构激动剂（GPR43），在hFFA2毛喉素诱导的cAMP分析中显示出相对于乙酸盐的左移乙酸盐剂量反应（IC50 = 0.7 µM）和111%的功效。

警告

毒性：标准处理（A）

重悬

复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

其他说明

Wang, Y., et al. 2009.Bioorg.Med. Chem. Lett.20, 493.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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The intestinal microbiota has been demonstrated to influence host metabolism, and has been proposed to affect the development of obesity and type 2 diabetes (T2D), possibly through short-chain fatty acids (SCFAs) produced by fermentation of dietary fiber. There are some
Bandik Föh et al.
PloS one, 17(3), e0266071-e0266071 (2022-03-26)
The microbially-derived short-chain fatty acid butyrate is a central inhibitor of inflammatory innate and adaptive immune responses. Emerging evidence suggests that butyrate induces differentiation of IL-10-producing (IL-10+) regulatory B cells. However, the underlying mechanisms of butyrate-driven modulation of B cell
Signe Schultz Pedersen et al.
The FEBS journal, 291(3), 566-583 (2023-11-21)
Butyrate, a gut microbial metabolite, has beneficial effects on glucose homeostasis and has become an attractive drug candidate for type 2 diabetes (T2D). Recently, we showed that butyrate protects pancreatic beta cells against cytokine-induced dysfunction. In this study, we explored
Guangwen Wang et al.
Journal of virology, 94(2) (2019-11-07)
Influenza A virus (IAV) coopts numerous host factors to complete its replication cycle. Here, we identify free fatty acid receptor 2 (FFAR2) as a cofactor for IAV entry into host cells. We found that downregulation of FFAR2 or Ffar2 expression
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