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Merck
CN
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主要文件

370679

Sigma-Aldrich

Guanosine 3′,5′-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt

A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM).

别名:

Guanosine 3′,5′-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt, Rp-8-Br-PET-cGMPS, Na, PKG Inhibitor VI

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About This Item

经验公式（希尔记法）:
C18H14BrN5O6PS · Na
CAS号:
172806-20-1
分子量:
562.27
MDL编号:
MFCD04037251
UNSPSC代码:
41106305
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

lyophilized

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

溶解性

water: 5 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

[Na+].[P+]1(O[C@@H]2[C@H](O[C@H]([C@@H]2O)[n]3c4c(nc3Br)C(=O)[n]5c(nc(c5)c6ccccc6)N4)CO1)([S-])[O-]

InChI

1S/C18H15BrN5O6PS.Na/c19-17-21-11-14(24(17)16-12(25)13-10(29-16)7-28-31(27,32)30-13)22-18-20-9(6-23(18)15(11)26)8-4-2-1-3-5-8;/h1-6,10,12-13,16,25H,7H2,(H,20,22)(H,27,32);/q;+1/p-1/t10-,12-,13-,16-,31?;/m1./s1

InChI key

SVMPQLHYWRTQCX-WKKXCKAJSA-M

一般描述

A metabolically-stable, competitive inhibitor of protein kinase G type Iα and Iβ (Ki = 30 nM) that also blocks cGMP-gated retinal type ion channels (IC50 = 25 µM). Also reported to block the activation of purified PKA type II (Ki = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 5 µmol = 2.81 mg.
A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM). Blocks cGMP-gated retinal type ion channels (IC50 = 25 µM) and the activation of purified PKA type II (Ki = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 1 µmol = 0.56 mg.

生化/生理作用

Cell permeable: yes
Primary Target
PKG1α & 1β
Product does not compete with ATP.
Reversible: no
Target Ki: 30 nM against PKG1α & 1β

警告

Toxicity: Standard Handling (A)

其他说明

Wei, J.Y., et al. 1996. Biochemistry35, 16815.
Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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