推荐产品
产品名称
颗粒酶B抑制剂I, The Granzyme B Inhibitor I controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated
颜色
off-white
溶解性
DMSO: 5 mg/mL
运输
ambient
储存温度
−20°C
一般描述
人和鼠丝氨酸蛋白酶颗粒酶B的弱抑制剂。还通过片段化蛋白2（一种与颗粒酶B同源的大鼠淋巴细胞颗粒蛋白酶）抑制淋巴细胞中与凋亡相关的DNA片段化（ID50=300 nM）。
人和鼠颗粒酶B的弱抑制剂。还通过片段化蛋白2（一种与颗粒酶B同源的大鼠淋巴细胞颗粒蛋白酶）抑制淋巴细胞中与凋亡相关的DNA片段化（ID50=300 nM）。
生化/生理作用
主要靶标
颗粒酶B
颗粒酶B
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标IC50：300 nM，针对片段化蛋白2引起的淋巴细胞凋亡相关DNA片段化
警告
毒性：标准处理（A）
序列
Z-Ala-Ala-Asp-CH₂Cl
重悬
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他说明
Gong, B., et al. 1999.Cell Growth Different.10, 491.
Shi, L., et al. 1992.J. Exp.Med. 176, 1521.
Odake, S., et al. 1991.Biochemistry30, 2217.
Shi, L., et al. 1992.J. Exp.Med. 176, 1521.
Odake, S., et al. 1991.Biochemistry30, 2217.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Yan Su et al.
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Penetration of immune cells into tumor cells was believed to be immune-suppressive via cell-in-cell (CIC) mediated death of the internalized immune cells. We unexpectedly found that CIC formation largely led to the death of the host tumor cells, but not
Ning-Ning Ji et al.
Frontiers in neurology, 10, 1306-1306 (2020-01-11)
Hippocampal neuronal apoptosis is a devastating consequence of cardiac arrest (CA) and subsequent cardiopulmonary resuscitation (CPR). In this study, we assessed the contribution of cytotoxic T lymphocyte (CTL)-derived toxic mediator granzyme B (Gra-b) to the hippocampal neuronal apoptosis following CA/CPR
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