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质量水平
检测方案
≥98% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
orange-red
溶解性
DMSO: 100 mg/mL
运输
ambient
储存温度
−20°C
InChI
1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
InChI key
LLJJDLHGZUOMQP-UHFFFAOYSA-N
一般描述
一种有效、细胞可渗透、可逆和ATP竞争性的蛋白激酶C(PKC)抑制剂,可抑制几种PKC同工酶(PKCα和PKCβ的IC50=7 nM;PKCγ的IC50=6 nM;PKCδ的IC50=10 nM;PKCζ的IC50=60 nM)。Gö 6983不能有效抑制PKCµ(IC50 = 20 µM),因此可用于区分PKCµ 与其他PKC同工酶。
一种有效、细胞可渗透的蛋白激酶C(PKC)抑制剂,已被证明可选择性抑制几种PKC同工酶(PKCα和PKCβ的IC50=7 nM;PKCγ的IC50=6 nM;PKCδ的IC50=10 nM;PKCζ的IC50=60 nM)。Gö 6983不能有效抑制PKCµ(IC50 = 20 µM),因此可用于区分PKCµ与其他PKC同工酶。
生化/生理作用
主要靶标
PKCα 和PKCβ
PKCα 和PKCβ
产物与ATP竞争。
可逆性:是
细胞可渗透性:是
靶标IC50:7 nM,对于PKCα 和PKCβ,6 nM,对于PKCγ;10 nM,对于PKCδ;60 nM,对于PKCζ
警告
毒性:标准处理(A)
其他说明
Wang, D., et al. 1998.J. Biol. Chem. 273, 33027.
Stempka, L., et al. 1997.J. Biol. Chem. 272, 6805.
Gschwendt, M., et al. 1996.FEBS Lett.392, 77.
Stempka, L., et al. 1997.J. Biol. Chem. 272, 6805.
Gschwendt, M., et al. 1996.FEBS Lett.392, 77.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Nature protocols, 1(2), 1044-1055 (2007-04-05)
Here we describe protocols for preparing and using fluorescent probes that respond to conformational changes by altered Foerster resonance energy transfer (FRET) efficiencies upon phosphorylation or, in principle, other posttranslational modifications (PTMs). The sensor protein, a truncated version of pleckstrin
Journal of immunology (Baltimore, Md. : 1950), 182(2), 1011-1020 (2009-01-07)
The MAPKs ERK, JNK, and p38 control diverse aspects of the immune response, including regulation of cytotoxin biology in NK cells and CTL. The chemokine CCL5 is coreleased with the cytotoxins, perforin, the granzymes, and granulysin, during the lethal hit
Journal of cellular physiology, 230(1), 105-115 (2014-06-10)
Epidermal Growth Factor (EGF) is a key regulator of epithelial paracellular permeability, a property that depends on tight junctions (TJ) and can be evaluated through the measurement of the transepithelial electrical resistance (TER). EGF increases the TER of MDCK monolayers
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