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质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
DMSO: 5 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
[n]1(c2c3[n](c4c(c3c5c(c2c6c1cccc6)CNC5=O)cccc4)C)CCC#N
InChI
1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
InChI key
VWVYILCFSYNJHF-UHFFFAOYSA-N
一般描述
一种细胞可渗透性、可逆和ATP竞争性的蛋白激酶C（PKC；大鼠脑的IC50=7.9 nM）抑制剂。选择性抑制Ca2+依赖性PKCα-同工酶（IC50=2.3 nM）和PKCβI（IC50=6.2 nM）。即使在微摩尔水平下，也不会影响不依赖Ca2+的PKCδ-，ε-和ζ-同工酶的激酶活性。据报道，在较高浓度（IC50=20 nM）下可抑制PKCµ。也可获得500 µg/mL的Gö 6976（目录编号365253）在无水DMSO中的溶液。
一种细胞可渗透性、可逆和ATP竞争性的蛋白激酶C（PKC；大鼠脑的IC50=7.9 nM）抑制剂。选择性抑制Ca2+依赖性PKCα-同工酶（IC50=2.3 nM）和PKCβI（IC50=6.2 nM）。即使在微摩尔水平下，也不会影响不依赖Ca2+的PKCδ-，ε-和ζ-同工酶的激酶活性。艾滋病病毒I型诱导的强效拮抗剂。
生化/生理作用
主要靶标
PKC
PKC
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：7.9 nM，针对大鼠脑PKC；针对Ca2+依赖性PKCα-同工酶和PKCβI分别为2.3 nM和6.2 nM
警告
毒性：标准处理（A）
重悬
复溶后，等分并冷冻保存（-20°C）。储备液可在-20°C最长稳定4个月。
其他说明
Gschwendt, M., et al. 1996.FEBS Lett.392, 77.
Wenzel-Seifert, K., et al. 1994.Biochem.Biophys.Res. Commun.200, 1536.
Martiny-Baron, G.M., et al. 1993.J. Biol. Chem.268, 9194.
Qatsha, K.A., et al. 1993.Proc.Natl.Acad.Sci. USA90, 4674.
Wenzel-Seifert, K., et al. 1994.Biochem.Biophys.Res. Commun.200, 1536.
Martiny-Baron, G.M., et al. 1993.J. Biol. Chem.268, 9194.
Qatsha, K.A., et al. 1993.Proc.Natl.Acad.Sci. USA90, 4674.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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