推荐产品
产品名称
GSK-3抑制剂XVI，CHIR99021, InSolution, ≥95%, 25 mM
质量水平
方案
≥95% (HPLC)
表单
liquid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
运输
ambient
储存温度
−70°C
SMILES字符串
Clc1c(ccc(c1)Cl)c2nc(ncc2c4[nH]cc(n4)C)NCCNc3ncc(cc3)C#N
InChI
1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
InChI key
AQGNHMOJWBZFQQ-UHFFFAOYSA-N
一般描述
一种细胞可渗透的氨基嘧啶化合物，可作为有效、ATP竞争性和高度选择性的GSK-3抑制剂（对于GSK-3α和GSK-3β，IC50分别为10和6.7 nM）。对46种其他酶几乎没有活性（对于20种激酶，IC50 >8.8 µM，对于23种非激酶，Ki ≥5 µM），并且仅与22种药理学相关受体（Kd ~4 µM）弱结合。该化合物可口服获得，并显示可有效改善体内鼠和大鼠2型糖尿病模型中的葡萄糖代谢。另提供该化合物的固体形式（目录号361559）。
生化/生理作用
主要靶标
GSK-3 α 和 β
GSK-3 α 和 β
可逆性：是
细胞可渗透性：是
靶标IC50：10和6.7 nM，针对GSK-3&alpha
包装
用惰性气体包装
警告
毒性：刺激性（B）
外形
GSK-3抑制剂XVI，CHIR99021（目录号361559）在DMSO中的25 mM（5 mg/430 µL）溶液。
其他说明
Mussmann, R., et al. 2007.J. Biol. Chem.282, 12030.
Ring, D.B., et al. 2003.Diabetes52, 588.
Bennett, C.N., et al. 2002.J. Biol. Chem.277, 30998.
Cline, G.W., et al. 2002.
Diabetes51, 2903.
Ring, D.B., et al. 2003.Diabetes52, 588.
Bennett, C.N., et al. 2002.J. Biol. Chem.277, 30998.
Cline, G.W., et al. 2002.
Diabetes51, 2903.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
188.6 °F - closed cup - (refers to pure substance)
闪点(°C)
87 °C - closed cup - (refers to pure substance)
Yanxin Fan et al.
STAR protocols, 4(1), 102073-102073 (2023-03-01)
Mitochondrial metabolism is critical in hematopoietic stem cell maintenance and differentiation. Here, we present a step-by-step protocol to efficiently differentiate human induced pluripotent stem cells into myeloid progenitors by a robust feeder- and serum-free system. Furthermore, we provide a protocol
Yanfei Deng et al.
Cellular reprogramming, 22(4), 217-225 (2020-07-17)
Wnt/β-Catenin signaling pathway plays an important role in maintaining self-renewal and pluripotency of human and mouse embryonic stem cells (ESCs). Activation of Wnt/β-Catenin signaling pathway by glycogen synthase kinase-3 (GSK3) inhibitor, the Wnt signaling agonist, could maintain the pluripotency of
Gayan I Balasooriya et al.
Nature communications, 13(1), 5984-5984 (2022-10-11)
Each mammalian autosomal gene is represented by two alleles in diploid cells. To our knowledge, no insights have been made in regard to allele-specific regulatory mechanisms of autosomes. Here we use allele-specific single cell transcriptomic analysis to elucidate the establishment
Chong Li et al.
Nature, 621(7978), 373-380 (2023-09-14)
The development of the human brain involves unique processes (not observed in many other species) that can contribute to neurodevelopmental disorders1-4. Cerebral organoids enable the study of neurodevelopmental disorders in a human context. We have developed the CRISPR-human organoids-single-cell RNA
Sunanjay Bajaj et al.
The EMBO journal, 40(23), e108714-e108714 (2021-10-19)
Inhibitory GABAergic interneurons migrate over long distances from their extracortical origin into the developing cortex. In humans, this process is uniquely slow and prolonged, and it is unclear whether guidance cues unique to humans govern the various phases of this
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门