361548
GSK-3β Inhibitor VII
The GSK-3β Inhibitor VII, also referenced under CAS 99-73-0, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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别名:
GSK-3β Inhibitor VII, α-4-Dibromoacetophenone, TPK I Inhibitor, Tau Protein Kinase I Inhibitor
经验公式（希尔记法）:
C8H6Br2O
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质量水平
检测方案
≥95% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated
protect from light
颜色
white
溶解性
DMSO: 5 mg/mL
运输
wet ice
储存温度
−20°C
InChI
1S/C8H6Br2O/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2
InChI key
FKJSFKCZZIXQIP-UHFFFAOYSA-N
一般描述
A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC50 = 0.5 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.
A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, selective, and non-ATP competitive inhibitor of GSK-3β (IC50 = 500 nM). Does not affect the activity of PKA even at concentrations as high as 100 µM.
生化/生理作用
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target IC50: 0.5 µM against GSK-3β
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
其他说明
Conde, S., et al. 2003. J. Med. Chem.46, 4631.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险声明
危险分类
Skin Corr. 1B
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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