352010
谷氨酰胺酶抑制剂，化合物968
Glutaminase Inhibitor, Compd 968, is a cell-permeable, reversible inhibitor of mitochondrial glutaminase. Represses growth & invasive activity in glutaminase upregulated fibroblasts and tumor cells.
别名:
谷氨酰胺酶抑制剂，化合物968, GAC抑制剂、GLS1抑制剂I、KGA抑制剂I、肾型谷氨酰胺酶抑制剂I、5-（3-溴-4-（二甲氨基）苯基）-2，2-二甲基-2，3，5，6-四氢苯并[a]菲啶-4（1H）-酮
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C27H27BrN2O
化学文摘社编号:
分子量:
475.42
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
谷氨酰胺酶抑制剂，化合物968, Glutaminase Inhibitor, Compd 968, is a cell-permeable, reversible inhibitor of mitochondrial glutaminase. Represses growth & invasive activity in glutaminase upregulated fibroblasts and tumor cells.
InChI key
NVFRRJQWRZFDLM-UHFFFAOYSA-N
SMILES string
O=C(CC(C)(C)C1)C2=C1C3=C(NC2C4=CC(Br)=C(C=C4)N(C)C)C=CC5=C3C=CC=C5
assay
≥99% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
相关类别
Disclaimer
毒性：标准处理（A）
General description
一种细胞可渗透的苯并菲啶酮化合物，可作为线粒体谷氨酰胺酶活性的变构和可逆抑制剂，并抑制谷氨酰胺酶上调的成纤维细胞和肿瘤细胞中的生长和侵袭活性（稳定表达Dbl，Cdc42-F28L，Rac-F28L或RhoC-F30L突变体以及SKBR3和MDA-MB231癌症细胞中的IC50 ≤ 10 µM）。在P-493B异种移植小鼠模型中显示可有效缩小肿瘤大小（200 µg/inj. i.p.，12天）。也可以提供10 mM的DMSO溶液（目录号5.06073）。
Other Notes
Wang, J.B., et al. 2010.Cancer Cell18, 207.
Packaging
用惰性气体包装
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Ying Zhang et al.
Oxidative medicine and cellular longevity, 2023, 9808100-9808100 (2023-01-20)
Ferroptosis, a newly identified form of cell death, plays critical roles in the development and chemoresistance of lung cancer. Tripartite motif 6 (TRIM6) acts as an E3-ubiquitin ligase and can promote the progression of human colorectal cancer. The present study
Hamed Alborzinia et al.
Nature cancer, 3(4), 471-485 (2022-04-29)
Aberrant expression of MYC transcription factor family members predicts poor clinical outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and mediates an antioxidant response to maintain redox balance. Here we show that MYCN induces massive lipid peroxidation on
Katharina Koch et al.
Cell death discovery, 6, 20-20 (2020-04-28)
Cancer cells upregulate anabolic processes to maintain high rates of cellular turnover. Limiting the supply of macromolecular precursors by targeting enzymes involved in biosynthesis is a promising strategy in cancer therapy. Several tumors excessively metabolize glutamine to generate precursors for
Kexin Zhang et al.
Molecular carcinogenesis, 57(11), 1566-1576 (2018-07-24)
Ferroptosis is a recently recognized form of regulated cell death driven by lipid-based reactive oxygen species (ROS) accumulation. However, the molecular mechanisms of ferroptosis regulation are still largely unknown. Here we identified a novel miRNA, miR-9, as an important regulator
Juan Vélez et al.
Biology, 10(1) (2021-01-21)
Cryptosporidium parvum is an apicomplexan zoonotic parasite recognized as the second leading-cause of diarrhoea-induced mortality in children. In contrast to other apicomplexans, C.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持