352010
谷氨酰胺酶抑制剂，化合物968
Glutaminase Inhibitor, Compd 968, is a cell-permeable, reversible inhibitor of mitochondrial glutaminase. Represses growth & invasive activity in glutaminase upregulated fibroblasts and tumor cells.
别名:
谷氨酰胺酶抑制剂，化合物968, GAC抑制剂、GLS1抑制剂I、KGA抑制剂I、肾型谷氨酰胺酶抑制剂I、5-（3-溴-4-（二甲氨基）苯基）-2，2-二甲基-2，3，5，6-四氢苯并[a]菲啶-4（1H）-酮
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关于此项目
经验公式（希尔记法）:
C27H27BrN2O
化学文摘社编号:
分子量:
475.42
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI key
NVFRRJQWRZFDLM-UHFFFAOYSA-N
SMILES string
O=C(CC(C)(C)C1)C2=C1C3=C(NC2C4=CC(Br)=C(C=C4)N(C)C)C=CC5=C3C=CC=C5
assay
≥99% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
相关类别
General description
一种细胞可渗透的苯并菲啶酮化合物，可作为线粒体谷氨酰胺酶活性的变构和可逆抑制剂，并抑制谷氨酰胺酶上调的成纤维细胞和肿瘤细胞中的生长和侵袭活性（稳定表达Dbl，Cdc42-F28L，Rac-F28L或RhoC-F30L突变体以及SKBR3和MDA-MB231癌症细胞中的IC50 ≤ 10 µM）。在P-493B异种移植小鼠模型中显示可有效缩小肿瘤大小（200 µg/inj. i.p.，12天）。也可以提供10 mM的DMSO溶液（目录号5.06073）。
Packaging
用惰性气体包装
Other Notes
Wang, J.B., et al. 2010.Cancer Cell18, 207.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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