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Merck
CN
所有图片(1)

文件

349254

Sigma-Aldrich

NS-398

A cell-permeable selective inhibitor of COX-2 in vitro.

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别名:
NS-398, N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide
经验公式（希尔记法）:
C13H18N2O5S
CAS号:
123653-11-2
分子量:
314.36
MDL编号:
MFCD00882995
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

检测方案

≥98% (TLC)

形式

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

pale yellow

溶解性

DMSO: 20 mg/mL

运输

ambient

储存温度

10-30°C

InChI

1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3

InChI key

KTDZCOWXCWUPEO-UHFFFAOYSA-N

一般描述

A cell-permeable selective inhibitor of COX-2 in vitro. Inhibits sheep placental COX-2 (IC50 = 3.8 µM) while COX-1 activity is unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations from 0.3 to 5 mg/kg.
A cell-permeable, selective inhibitor of cyclooxygenase-2 (COX-2) in vitro. Inhibits sheep placenta COX-2 (IC50 = 3.8 µM) while COX-1 activity is completely unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations of 0.3 to 5 mg/kg. Does not produce any significant gastrointestinal lesions even at single oral doses of 1000 mg/kg. A useful tool to explore the role of COX-2 in physiologic and pathophysiologic processes.

生化/生理作用

Cell permeable: yes
Primary Target
COX-2
Product does not compete with ATP.
Reversible: no
Target IC50: 3.8 µM against COX-2

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

其他说明

Ouellet, M., and Percival, M.D. 1995. Biochem. J.306, 247.
Futaki, N., et al. 1994. Prostaglandins47, 55.
Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol.81, 259.
Futaki, N., et al. 1993. Gen. Pharmacol.24, 105.
Futaki, N., et al. 1993. J. Pharm.Pharmacol.45, 753.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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