345752
Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk
Has been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma.
别名:
Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk, Neu5Acα2,8Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, 2NH₄
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About This Item
经验公式（希尔记法）:
C70H123N3O30 · 2NH4
分子量:
1522.80
UNSPSC代码:
12352211
NACRES:
NA.77
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质量水平
方案
≥98% (TLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
溶解性
water: 1 mg/mL
chloroform/methanol (2:1): soluble
运输
ambient
储存温度
−20°C
一般描述
Has been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma. Reported to disrupt mitochondrial transmembrane potential and induce apoptosis in tumor cells by a caspase-independent mechanism. Antibodies to GD3 can induce partial remission of tumor growth in animals and in humans via enhancement of cytotoxic and proliferative responses of lymphocytes. M.W. 1577.0 (based on tricosanoyl - 23:0).
警告
Toxicity: Irritant (B)
其他说明
DeMaria, R., et al. 1997. Science 277, 1652.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Sumeyye Cavdarli et al.
Cells, 10(6) (2021-07-03)
The O-acetylated form of GD2, almost exclusively expressed in cancerous tissues, is considered to be a promising therapeutic target for neuroectoderm-derived tumors, especially for breast cancer. Our recent data have shown that 9-O-acetylated GD2 (9-OAcGD2) is the major O-acetylated ganglioside
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