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Merck
CN
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文件

安全信息

344845

Sigma-Aldrich

Fumagillin, Aspergillus fumigatus

Antiprotozoal agent and angiogenesis inhibitor.

别名:

Fumagillin, Aspergillus fumigatus

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About This Item

经验公式(希尔记法):
C26H34O7
CAS号:
分子量:
458.54
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

检测方案

≥90% (HPLC)

形式

powder

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

white to off-white

溶解性

methanol: 5 mg/mL

运输

ambient

储存温度

2-8°C

InChI

1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20?,23-,24-,25+,26+/m1/s1

InChI key

NGGMYCMLYOUNGM-IJIYPQOHSA-N

一般描述

An inhibitor of angiogenesis. Has selective cytostatic effects against ras transformed cells (IC50 = 10 pM). Antiprotozoal agent active against sporozoan parasites in bees and myxozoan parasites in fish.
Antiprotozoal agent and angiogenesis inhibitor.
Antiprotozoal agent and angiogenesis inhibitor. Acts as an inhibitor of methionine amino-peptidase 2.

生化/生理作用

Primary Target
Methionine amino-peptidase 2
Product does not compete with ATP.

包装

Packaged under inert gas

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Zhang, P., et al. 2002. J. Biomed. Sci.9, 34.
Stepien, H., et al. 1996. J. Endocrinol.150, 99.
Abrams, J.S., et al. 1994. Cancer74, 1164.
Jenkins, D.C., et al. 1993. Br. J. Cancer68, 856.
Le Querrec, A., et al. 1993. Baillieres Clin. Hematol.6, 711.
Molnar, K. 1993. Acta Vet. Hung. 41, 51.
Kusada, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
Brackett, J.M., et al. 1988. J. Agric. Food Chem.36, 762.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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