344827
岩藻糖基转移酶抑制剂，2F-过乙酰基-岩藻糖
2F-Peracetyl-Fucose is a cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic.
别名:
岩藻糖基转移酶抑制剂，2F-过乙酰基-岩藻糖, （3S，4R，5R，6S）-3-氟-6-甲基四氢-2H-吡喃-2，4，5-三基三乙酸酯
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所有图片(1)
About This Item
经验公式（希尔记法）:
C12H17FO7
分子量:
292.26
UNSPSC代码:
12352111
NACRES:
NA.77
质量水平
检测方案
≥98% (NMR)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 10 mg/mL
运输
ambient
储存温度
−20°C
一般描述
一种细胞可渗透的氟化岩藻糖衍生物，在其摄取和代谢转化为GDP-岩藻糖模拟物后作为岩藻糖基转移酶的抑制剂。用这种抑制剂对HL-60细胞进行治疗显示，Lewis-X和SLex在3天内完全消失。 还消除了P-选择素的结合，并在E-选择素和P-选择素包被的表面上表现出更快的滚动细胞。即使在200 µM水平下，也不会影响细胞活率或其倍增时间。
生化/生理作用
主要靶标
岩藻糖基转移酶
岩藻糖基转移酶
可逆性：是
细胞可渗透性：是
包装
用惰性气体包装
警告
毒性：标准处理（A）
重悬
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他说明
Rillahan, C., et al. 2012..Nat. Chem. Bio.8, 661.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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