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COA分析证书/COQ

344096

Fluvastatin, Sodium Salt

Name: Fluvastatin, Sodium Salt
Brand: MM

InSolution, ≥98% inhibitor of HMG-CoA reductase

别名:

InSolution Fluvastatin, Sodium Salt, (±)-(3Rʹ,5Sʹ,6E)-7-(3-(4-Fluorophenyl)-1-isopropylindol-2-yl)-3,5-dihydroxy-6-heptenoate, sodium

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About This Item

经验公式（希尔记法）:

C₂₄H₂₅FNNaO₄

CAS号:

93957-55-2

分子量:

433.45

MDL编号:

MFCD08063391

UNSPSC代码:

12352200

NACRES:

NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

liquid

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze
avoid repeated freeze/thaw cycles
protect from light

运输

dry ice

储存温度

−70°C

InChI

1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;/t18-,19-;/m0./s1

InChI key

ZGGHKIMDNBDHJB-RPQBTBOMSA-M

一般描述

A synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent. Unlike Lovastatin (Cat. No. 438185), Mevastatin (Cat. No. 474700), and Simvastatin (Cat. No. 567020), it does not require activation prior to use for in vitro studies. Reduces the basal MMP-1 levels in culture media of endothelial cells in a time- and dose-dependent manner. Fluvastatin is metabolized in the liver, primarily via hydroxylation of the indole ring at the 5- and 6-positions. N-Dealkylation and β-oxidation of the side-chain also occurs. The hydroxy metabolites are also reported to have some pharmacologic activity.

生化/生理作用

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

外形

A 10 mM (10 mg/2.13 ml) solution of Fluvastatin, Sodium Salt (344095) in H₂O.

其他说明

Yamamoto, A., et al. 2001. J. Pharm. Pharmacol.53, 227.
Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol.52, 145.
Ikeda, U., et al. 2000. Hypertension36, 325.
Levy, R.I., et al. 1993. Circulation87 (4 Suppl.), III45.
Tse, F.L.S. et al. 1992. J. Clin. Pharmacol.32, 630.
Yuan, J., et al. 1991. Atherosclerosis87, 147.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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