343333
5-氟-2′-脱氧尿苷
≥98% (HPLC), solid, thymidylate synthase inhibitor, Calbiochem®
别名:
5-氟-2′-脱氧尿苷, FdUrd，FUdR，5-FdU，氟尿苷
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关于此项目
经验公式（希尔记法）:
C9H11FN2O5
化学文摘社编号:
分子量:
246.19
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
5-氟-2′-脱氧尿苷, Experimental anticancer agent shown to have activity against a variety of malignant neoplasms, including mouse mammary tumors and colorectal carcinomas.
SMILES string
Fc1[c]([nH][c]([n](c1)[C@@H]2O[C@@H]([C@H](C2)O)CO)=O)=O
InChI
1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChI key
ODKNJVUHOIMIIZ-RRKCRQDMSA-N
description
Merck USA index - 14, 4112
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
aqueous buffer: 1 mg/mL
water: 1 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
主要靶标
实验性抗癌药
实验性抗癌药
产物不与ATP竞争。
可逆：否
细胞渗透性：否
Disclaimer
毒性：有毒 & 致癌/致畸性（G）
General description
一种实验性抗癌药，显示出对多种恶性肿瘤（包括小鼠乳腺肿瘤和结肠直肠癌）具有活性。
Other Notes
Nakagama, H., et al. 2001.Jpn.J. Clin. Oncol.31, 251.
Malmberg, M., et al. 1993.Cell Prolif.26, 291.
Malmberg, M., et al. 1993.Cell Prolif.26, 291.
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Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
Sheng Xiao et al.
iScience, 24(11), 103263-103263 (2021-11-12)
Recent improvements in genetically encoded voltage indicators enabled optical imaging of action potentials and subthreshold transmembrane voltage in vivo. To perform high-speed voltage imaging of many neurons simultaneously over a large anatomical area, widefield microscopy remains an essential tool. However, the
Inhibition of Chk2 promotes neuroprotection, axon regeneration, and functional recovery after CNS injury.
Taylor, et al.
Science Advances, 8, eabq2611-eabq2611 (2022)
Thanasis Rogdakis et al.
Biomedicines, 10(3) (2022-03-26)
Neurotrophins are growth factors that exert important neuroprotective effects by preventing neuronal death and synaptic loss. Nerve Growth Factor (NGF) acts through the activation of its high-affinity, pro-survival TrkA and low-affinity, pro-apoptotic p75NTR receptors. NGF has been shown to slow
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