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质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: <4 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
[s]1c2c(c(c1NC(=O)c3cc(c(cc3)OC)OC)C(=O)N)CCCC2
InChI
1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
InChI key
FSPQCTGGIANIJZ-UHFFFAOYSA-N
一般描述
A cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor (IC50 = 42 nM) with little effect against a panel of 22 other kinases (IC50 ≥3 µM). Shown to exhibit antiproliferative properties against the human acute myelogenous leukemia cell line MV4-11 (IC50 = 340 nM) expressing constitutively active Flt-3.
生化/生理作用
Cell permeable: yes
Product competes with ATP.
Reversible: no
Target IC50: 42 nM against Flt-3
包装
Packaged under inert gas
警告
Toxicity: Irritant (B)
其他说明
Patch, R.J., et al. 2006. Bioorg. Med. Chem. Lett.16, 3282.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
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