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Merck
CN
所有图片(1)

主要文件

341631

Sigma-Aldrich

Bovine Fibronectin

from bovine plasma, liquid, suitable for cell culture

别名:

纤连蛋白,牛血浆

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About This Item

CAS号:
MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.75

产品名称

纤连蛋白,牛血浆,

描述

Merck USA index - 14, 4075

质量水平

表单

liquid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
avoid repeated freeze/thaw cycles

运输

dry ice

储存温度

−20°C

一般描述

纤连蛋白是一种细胞外基质(ECM)糖蛋白。它在各种细胞类型中表达。纤连蛋白以二聚体形式存在,由相同的亚基组成,它们在C端通过二硫键共价连接。

应用

牛血浆纤连蛋白已用作细胞外基质(ECM)底物以涂覆器皿或聚丙烯酰胺水凝胶,进而粘附:
  • 人类黑色素瘤癌细胞
  • 人乳腺上皮细胞
  • 小鼠胚胎成纤维细胞

生化/生理作用

纤连蛋白在细胞粘附、生长、迁移和分化中发挥作用。它与一些分子结合,如整合素、肝素、纤维蛋白和胶原蛋白。

包装

请参考特定浓度批号的标签。

警告

毒性:标准处理(A)

外形

在150 mM NaCl,20 mM磷酸钠缓冲液(pH 7.3)中。

重悬

初次融化后,等分并冷冻(-20°C)。

分析说明

通过SDS-PAGE获得单一条带

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

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Purva Singh et al.
Annual review of cell and developmental biology, 26, 397-419 (2010-08-10)
In the process of matrix assembly, multivalent extracellular matrix (ECM) proteins are induced to self-associate and to interact with other ECM proteins to form fibrillar networks. Matrix assembly is usually initiated by ECM glycoproteins binding to cell surface receptors, such
Jordi Pijuan et al.
Frontiers in cell and developmental biology, 7, 107-107 (2019-07-02)
Cell migration is a key procedure involved in many biological processes including embryological development, tissue formation, immune defense or inflammation, and cancer progression. How physical, chemical, and molecular aspects can affect cell motility is a challenge to understand migratory cells
Guillaume Jacquemet et al.
The Journal of cell biology, 216(10), 3387-3403 (2017-08-03)
Defective filopodia formation is linked to pathologies such as cancer, wherein actively protruding filopodia, at the invasive front, accompany cancer cell dissemination. Despite wide biological significance, delineating filopodia function in complex systems remains challenging and is particularly hindered by lack
Joseph A Brazzo et al.
Journal of cell science, 134(12) (2021-06-22)
Cell cycle control is a key aspect of numerous physiological and pathological processes. The contribution of biophysical cues, such as stiffness or elasticity of the underlying extracellular matrix (ECM), is critically important in regulating cell cycle progression and proliferation. Indeed
Patrizia M Spoerri et al.
Nature materials, 19(2), 218-226 (2020-01-22)
Haematopoietic cells and platelets employ G-protein-coupled receptors (GPCRs) to sense extracellular information and respond by initiating integrin-mediated adhesion. So far, such processes have not been demonstrated in non-haematopoietic cells. Here, we report that the activation of protease-activated receptors PAR1 and

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