FeTMPyP

Catalyzes the isomerization of peroxynitrite (ONOO^–) to nitrate (NO₃^–) under physiological conditions and at realistic dose-derived concentrations (K_cat = 2.2 x 10⁶ M^-1s^-1). Effectively prevents the oxidation of lipid components by peroxynitrite. Also catalytically decomposes superoxide radicals (O₂^·). Irradiation of the aqueous solution at 335 nm releases hydroxyl (OH·) radicals. FeTMPyP can also serve as a potential for drug detoxification of reactive oxygen species (ROS).

Catalyzes the isomerization of peroxynitrite (ONOO^-) to nitrate (NO₃^-) under physiological conditions and at realistic dose-derived concentrations (K_cat = 2.2 x 10⁶ M^-1s^-1). Effectively prevents the oxidation of lipid components by peroxynitrite. Also decomposes superoxide radicals (O₂^•) catalytically. Irradiation of the aqueous solution at 335 nm releases hydroxyl (OH^•) radicals. FeTMPyP can also serve as a potential drug for reactive oxygen species (ROS) detoxification.

Cell permeable: no

Kcat = 2.2 x 106 M-1s-1 in catalyzing the isomerization of peroxynitrite (ONOO-) to nitrate (NO3-) under physiological conditions

Primary Target
Peroxynitrite (ONOO-)

Product does not compete with ATP.

Reversible: no

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 7493.
Hunt, J.A., et al. 1997. Chem. Biol. 4, 845.
Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
Stern, M.K., et al. 1996. J. Am. Chem. Soc. 118, 8735.
Faraggi, M., et al. 1984. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.46, 703.

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