推荐产品
产品名称
Ezrin抑制剂，NSC668394, The Ezrin Inhibitor, NSC668394 controls the biological activity of Ezrin.
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
red-orange
溶解性
DMSO: 50 mg/mL, clear, red-orange
运输
ambient
储存温度
−20°C
SMILES字符串
O=C1C=C(NCCC2=CC(Br)=C(O)C(Br)=C2)C(C3=C1C=CC=N3)=O
InChI key
OHPHDPYJEHZGDE-UHFFFAOYSA-N
一般描述
一种细胞可渗透的喹啉，以可逆的方式直接与ezrin（Kd = 12.6 µM）结合，并在体外抑制Thr567处PKCι-介导的ezrin磷酸化（IC50 = 8.1 µM）和ezrin-actin结合。它还从1到10 µM剂量依赖性地抑制HUVEC细胞单层中的鼠成骨肉瘤K7M2细胞侵袭。在10 µM时，它会导致斑马鱼独特的发育缺陷，其特征是眼祖细胞的运动性降低。此外，该小分子可在10 µM的离体小鼠肺器官培养测定中阻止转移性生长，并在2.26 mg/kg/天的体内减弱小鼠肺模型中ezrin依赖性OS转移性的生长。
包装
用惰性气体包装
警告
毒性：标准处理（A）
重悬
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他说明
Bulut, G., et al. 2011.Oncogene31, 269.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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