推荐产品
质量水平
检测方案
≥95% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 25 mg/mL
运输
ambient
储存温度
10-30°C
InChI
1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
InChI key
VJJPUSNTGOMMGY-MRVIYFEKSA-N
一般描述
一种细胞可渗透的拓扑异构酶II抑制剂（IC50 = 59.2 µM）。一种鬼臼毒素衍生物（目录编号540040），对许多肿瘤（包括生殖细胞肿瘤、小细胞肺癌和恶性淋巴瘤）具有主要活性。在小鼠胸腺细胞和HL-60人白血病细胞中诱导凋亡。
一种细胞可渗透的鬼臼毒素衍生物，可用作拓扑异构酶II抑制剂（IC50 = 59.2 µM），对许多肿瘤（包括生殖细胞肿瘤、小细胞肺癌和恶性淋巴瘤）具有主要活性。在小鼠胸腺细胞和HL-60人白血病细胞中诱导凋亡。
生化/生理作用
主要靶标
拓扑异构酶2
拓扑异构酶2
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标IC50：59.2 µM，抑制拓扑异构酶II
警告
毒性：有害 & 致癌/致畸性（E）
重悬
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他说明
De Lange, A.M., et al. 1995.J. Virol.69, 2082.
Kaufman, S.H., et al. 1993.Cancer Res.53, 3976.
Onishi, Y., et al. 1993.Biochim.Biophys.Acta1175, 147.
Terada, T., et al. 1993.J. Med. Chem. 36, 1689.
Wazniak, A.J., et al. 1991.J. Clin. Oncol.9, 70.
Einhorn, L.H., et al. 1988.J. Clin. Oncol.6, 451.
Issel, B.F.1982.Cancer Chemother.Pharmacol.7, 73.
Kaufman, S.H., et al. 1993.Cancer Res.53, 3976.
Onishi, Y., et al. 1993.Biochim.Biophys.Acta1175, 147.
Terada, T., et al. 1993.J. Med. Chem. 36, 1689.
Wazniak, A.J., et al. 1991.J. Clin. Oncol.9, 70.
Einhorn, L.H., et al. 1988.J. Clin. Oncol.6, 451.
Issel, B.F.1982.Cancer Chemother.Pharmacol.7, 73.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Carc. 1B - Repr. 2
WGK
WGK 3
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