product name
Erastin, A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality.
质量水平
检测方案
≥98% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 50 mg/mL
运输
wet ice
储存温度
−20°C
InChI
1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
InChI key
BKQFRNYHFIQEKN-UHFFFAOYSA-N
一般描述
具有致癌基因选择性杀伤力的细胞可渗透的哌嗪基-喹唑啉酮化合物。显示结合线粒体电压依赖性阴离子通道(VDAC)并改变其门控;在几种人类肿瘤中快速诱导氧化性,非凋亡性细胞死亡,这些肿瘤在RAS-RAF-MEK信号传导中具有激活突变(在BJ-TERT/LT/ST/RASV12细胞中EC50 = 6.0 µM)。
包装
用惰性气体包装
警告
毒性:标准处理(A)
重悬
复溶后,等分并冷冻保存(-20°C)。储备溶液在-20°C下可稳定保存至多6个月。
其他说明
Yagoda, N., et al. 2007.Nature447, 864.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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