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Merck
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329600

Sigma-Aldrich

Erastin

≥98% (HPLC), solid, antitumor agent, Calbiochem®

别名:

Erastin, 2-(1-(4-(2-(4-氯苯氧基)乙酰基)-哌嗪-1-基)-乙基)-3-(2-乙氧基苯基)-3H-喹唑啉-4-酮

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About This Item

经验公式(希尔记法):
C30H31ClN4O4
分子量:
547.04
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77

product name

Erastin, A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality.

质量水平

检测方案

≥98% (HPLC)

形式

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

white

溶解性

DMSO: 50 mg/mL

运输

wet ice

储存温度

−20°C

InChI

1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3

InChI key

BKQFRNYHFIQEKN-UHFFFAOYSA-N

一般描述

具有致癌基因选择性杀伤力的细胞可渗透的哌嗪基-喹唑啉酮化合物。显示结合线粒体电压依赖性阴离子通道(VDAC)并改变其门控;在几种人类肿瘤中快速诱导氧化性,非凋亡性细胞死亡,这些肿瘤在RAS-RAF-MEK信号传导中具有激活突变(在BJ-TERT/LT/ST/RASV12细胞中EC50 = 6.0 µM)。

包装

用惰性气体包装

警告

毒性:标准处理(A)

重悬

复溶后,等分并冷冻保存(-20°C)。储备溶液在-20°C下可稳定保存至多6个月。

其他说明

Yagoda, N., et al. 2007.Nature447, 864.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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