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Merck
CN
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主要文件

安全信息

325001

Sigma-Aldrich

Epothilone B, Synthetic

A structural analog of Epothilone A with similar biological properties.

别名:

Epothilone B, Synthetic, EpoB

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About This Item

经验公式（希尔记法）:
C27H41NO6S
CAS号:
152044-54-7
分子量:
507.68
MDL编号:
MFCD02101921
UNSPSC代码:
12352200

质量水平

100

方案

≥99% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

white to off-white

溶解性

DMSO: 10 mg/mL

运输

ambient

储存温度

−20°C

InChI

1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1

InChI key

QXRSDHAAWVKZLJ-PVYNADRNSA-N

一般描述

A structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells).
A structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multi drug resistant (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells).

生化/生理作用

Cell permeable: no
Primary Target
P-glycoprotein-expressing multidrug resistant (MDR) cells
Product does not compete with ATP.
Reversible: no
Target IC50: 2 nM for MDR CCRF-CEM/VBL100 cells

警告

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.

其他说明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Giannakakou, P., et al. 2000. Proc. Natl. Acad. Sci. USA97, 2904.
Chou, T.-C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 9642.
Kowalski, R.J., et al. 1997. J. Biol. Chem. 272, 2534.
Muhlradt, P.F., and Sasse, F. 1997. Cancer Res. 57, 3344.
Nicolaou, K.C., et al. 1997. Nature 387, 268.
Bollag, D.M., et al. 1995. Cancer Res. 55, 2325.

法律信息

Not available for sale in Germany.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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