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324895

eIF-2α抑制剂，Salubrinal

Name: eIF-2α抑制剂，Salubrinal
Brand: MM

eIF-2α Inhibitor, Salubrinal, CAS 304475-63-6, is a cell-permeable, selective inhibitor of the phosphatase complexes that dephosphorylate eIF-2α. Protects cells against ER stress-induced apoptosis.

别名:

eIF-2α抑制剂，Salubrinal, Sal

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About This Item

经验公式（希尔记法）:

C₂₁H₁₇Cl₃N₄OS

CAS号:

304475-63-6

分子量:

479.81

UNSPSC代码:

12352200

NACRES:

NA.77

质量水平

100

检测方案

≥90% (HPLC)

形式

solid

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze
protect from light

颜色

beige

溶解性

DMSO: 10 mg/mL

运输

wet ice

储存温度

−20°C

一般描述

一种对真核翻译起始因子2亚基α（eIF-2α）进行去磷酸化的磷酸酶复合物的细胞渗透性和选择性抑制剂。显示提供针对ER应激诱导的凋亡的保护（在用750 ng/ml衣霉素（目录编号654380）刺激的PC12细胞中EC₅₀ = ~15 µM）。防止体外Vero细胞（减少斑块形成的IC₅₀ = ~3 µM）和体内小鼠角膜感染模型中的HSV复制。也可以50 mM的DMSO溶液（目录号324897）提供。

一种对真核翻译起始因子2亚基α（eIF-2α）进行去磷酸化的磷酸酶复合物的细胞渗透性和选择性抑制剂。显示提供针对ER应激诱导的凋亡的保护（在用750 ng/ml衣霉素（目录编号654380）刺激的PC12细胞中EC₅₀ ~15 µM）。防止体外Vero细胞（减少斑块形成的IC₅₀ 3 µM）和体内小鼠角膜感染模型中的HSV复制。

生化/生理作用

主要靶标
elF-2α

产物不与ATP竞争。

可逆：否

细胞可渗透性：是

靶标IC₅₀：3 µM，阻止Vero细胞中的HSV复制。

包装

用惰性气体包装

警告

毒性：标准处理（A）

重悬

复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

其他说明

Boyce, M., et al. 2005.Science307, 935.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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