product name
EIF2AK3活化剂，CCT020312, The EIF2AK3 Activator, CCT020312 modulates the biological activity of EIF2AK3.
质量水平
检测方案
≥98% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow-white
溶解性
DMSO: 50 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
O=C1C(C2=NN(C(CCN(CC)CC)=O)C(C3=CC=C(Br)C=C3)C2)=C(C4=CC=CC=C4)C5=CC(Br)=CC=C5N1
一般描述
一种二氢吡唑衍生物，作为真核翻译起始因子2-α激酶3（eIF2AK3/PERK）的选择性激活剂，并增加HT29和MCF7细胞中EIF2A在Ser51位点的磷酸化。不抑制细胞周期蛋白依赖性激酶的活性，但引起细胞周期蛋白D表达的快速丧失。还显示阻断HT29细胞中的Rb蛋白磷酸化（EC50 = 4.2 µM）。据报道，可使紫杉烷诱导的EIF2A磷酸化缺陷的癌症细胞对紫杉醇治疗敏感。即使去除细胞增殖（GI50 = 3.1 µM），也能诱导长期抑制细胞增殖。
包装
用惰性气体包装
警告
毒性：标准处理（A）
重悬
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他说明
Stockwell, S. R., et al. 2011.Plos One In press.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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