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Merck
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主要文件

324788

Sigma-Aldrich

死亡相关蛋白激酶(DAPK)抑制剂

The DAPK Inhibitor, also referenced under CAS 315694-89-4, controls the biological activity of DAPK.

别名:

死亡相关蛋白激酶(DAPK)抑制剂, （4Z）-4-（3-吡啶基亚甲基）-2-苯乙烯基-恶唑-5-酮，死亡相关蛋白激酶抑制剂

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10 MG
CN¥1,541.00

CN¥1,541.00

预计发货时间May 16, 2025详情

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10 MG
CN¥1,541.00

About This Item

经验公式（希尔记法）:
C17H12N2O2
CAS号:
315694-89-4
分子量:
276.29
MDL编号:
MFCD02329887
UNSPSC代码:
12352200
NACRES:
NA.77

CN¥1,541.00

预计发货时间May 16, 2025详情

登录查看协议价

质量水平

100

方案

≥95% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

yellow

溶解性

DMSO: 25 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

N1=C(OC(=O)\C\1=C/c3cnccc3)\C=C\c2ccccc2

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此商品
528282526524567731
DAPK Inhibitor The DAPK Inhibitor, also referenced under CAS 315694-89-4, controls the biological activity of DAPK.

324788

DAPK Inhibitor

Polo-like Kinase Inhibitor I The Polo-like Kinase Inhibitor I, also referenced under CAS 916985-21-2, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

528282

Polo-like Kinase Inhibitor I

PIM1/2 Kinase Inhibitor VI The PIM1/2 Kinase Inhibitor VI, also referenced under CAS 587852-28-6, controls the biological activity of PIM1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

526524

PIM1/2 Kinase Inhibitor VI

Sphingosine Kinase Inhibitor The Sphingosine Kinase Inhibitor, also referenced under CAS 1177741-83-1, controls the biological activity of Sphingosine Kinase. This small molecule/inhibitor is primarily used for Cell Signaling applications.

567731

Sphingosine Kinase Inhibitor

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

一般描述

一种恶唑酮化合物，可作为有效的、ATP竞争性和高度选择性的死亡相关蛋白激酶（DAPK）抑制剂（对于DAPK1和DAPK3，IC50分别为69和225 nM，具有10 µM ATP），同时表现出大大降低的活性或即使在高浓度为10 µM的情况下，对48种其他激酶也没有活性。

包装

用惰性气体包装

警告

毒性：标准处理（A）

重悬

复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多6个月。

其他说明

Okamoto, M., et al. 2009.J. Med. Chem.52, 7323.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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    Fraser Thomas et al.
    Molecular oncology, 14(6), 1268-1281 (2020-04-20)
    Cross-linking of the B-cell receptor (BCR) induces transcriptional activation of immediate early genes (IEGs) including EGR1 and DUSP2 in chronic lymphocytic leukaemia (CLL). Here, we have shown that this transcriptional activation correlated with histone H3 threonine 6 and 11 phosphorylation.
    Katsuya Onishi et al.
    FEBS letters, 597(5), 643-656 (2023-02-02)
    Stiffness of the extracellular matrix regulates various biological responses, but the response mechanisms are poorly understood. Here, we found that the nuclear diphosphorylated myosin regulatory light chain (2P-MRLC) is a critical mechanomediator that suppresses apoptosis in response to substrate stiffness.
    Mariko Takahashi et al.
    Nature immunology, 22(4), 485-496 (2021-03-27)
    Evasion of host immunity is a hallmark of cancer; however, mechanisms linking oncogenic mutations and immune escape are incompletely understood. Through loss-of-function screening of 1,001 tumor suppressor genes, we identified death-associated protein kinase 3 (DAPK3) as a previously unrecognized driver

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