324696
Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide
A specific chromogenic substrate for human neutrophil elastase.
别名:
Elastase Substrate I, Colorimetric
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关于此项目
经验公式（希尔记法）:
C27H38N6O9
化学文摘社编号:
分子量:
590.63
UNSPSC Code:
12352200
NACRES:
NA.54
MDL number:
产品名称
Elastase Substrate I, Colorimetric, A specific chromogenic substrate for human neutrophil elastase.
SMILES string
[N+](=O)([O-])c1ccc(cc1)N[C@@H](C(C)C)C(=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCC(=O)OC)C)C
InChI
1S/C27H38N6O9/c1-15(2)23(30-18-8-10-19(11-9-18)33(40)41)26(38)31-25(37)20-7-6-14-32(20)27(39)17(4)29-24(36)16(3)28-21(34)12-13-22(35)42-5/h8-11,15-17,20,23,30H,6-7,12-14H2,1-5H3,(H,28,34)(H,29,36)(H,31,37,38)/t16-,17-,20-,23-/m0/s1
InChI key
JWYKDZIEIWGSBN-OSAZLGQLSA-N
assay
≥95% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Cell permeable: no
Kcat/Km = 120,000 vs. 2700 for pancreatic elastase
Primary Target
Chromogenic substrate for human neutrophil elastase
Chromogenic substrate for human neutrophil elastase
Product does not compete with ATP.
Reversible: no
Disclaimer
Toxicity: Standard Handling (A)
General description
A specific chromogenic substrate for human neutrophil elastase (Kcat/Km = 120,000 vs. 2700 for pancreatic elastase). Cleavage can be monitored at ~410 nm. Sold on the basis of substrate content.
Specific chromogenic substrate for human neutrophil elastase (kcat/Km = 120,000 versus pancreatic elastase: kcat/Km = 2,700). Cleavage can be monitored at 410 nm using ε = 8,800.
Other Notes
Barrett, A.J., et al. 1989. Biochim. J.260, 259.
Nakajima, K., et al. 1979. J. Biol. Chem.254, 4027.
Nakajima, K., et al. 1979. J. Biol. Chem.254, 4027.
MeOSuc-Ala-Ala-Pro-Val-pNA
Physical form
Lyophilized from a solution containing 90 mg D-mannitol and 10 mg substrate.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Ning Luan et al.
Toxins, 11(12) (2019-12-11)
Elastase is a globular glycoprotein and belongs to the chymotrypsin family. It is involved in several inflammatory cascades on the basis of cleaving the important connective tissue protein elastin, and is strictly regulated to a balance by several endogenous inhibitors.
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