324693
Emetine dihydrochloride
≥98% (HPLC), solid, protein synthesis blocker, Calbiochem®
别名:
Emetine, Dihydrochloride, 6ʹ,7ʹ,10,11-Tetramethoxyemetan, 2HCl
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关于此项目
经验公式（希尔记法）:
C29H40N2O4 · 2HCl
化学文摘社编号:
分子量:
553.56
UNSPSC Code:
41116107
NACRES:
NA.77
MDL number:
产品名称
Emetine, Dihydrochloride, Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha.
SMILES string
[Cl-].[Cl-].N21[C@@H](C[C@@H]([C@H](C2)CC)C[C@H]4NCCc5c4cc(c(c5)OC)OC)c3c(cc(c(c3)OC)OC)CC1.[H+].[H+]
InChI
1S/C29H40N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H/t18-,21-,24+,25-;;/m0../s1
InChI key
JROGBPMEKVAPEH-GXGBFOEMSA-N
description
Merck USA index - 14, 3559
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
white to off-white
white
solubility
water: 20 mg/mL
ethanol: soluble
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: no
Primary Target
Movement of ribosomes along the mRNA
Movement of ribosomes along the mRNA
Product does not compete with ATP.
Reversible: no
Target IC50: ≤1 µM as a specific inhibitor of HIF-2α protein stability and transcriptional activity
Disclaimer
Toxicity: Highly Toxic (H)
General description
Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Interferes with cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC50 ≤1 µM.
Principle alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC50 ≤1 µM.
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Kong, H.S., et al. 2010. Mol. Pharmacol.in press.
Khan, M.A. 1995. Prog. Neurobiol.46, 541.
Kokuho, T., et al. 1995. Immunobiology193, 42.
Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett.93, 157.
Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
Filley, E.A., and Rook, G.A. 1991. Infect. Immun.59, 2567.
Landis, R.C., et al. 1991. J. Immunol.146, 128.
Schweighoffer, T., et al. 1991. Histochemistry96, 93.
Khan, M.A. 1995. Prog. Neurobiol.46, 541.
Kokuho, T., et al. 1995. Immunobiology193, 42.
Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett.93, 157.
Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
Filley, E.A., and Rook, G.A. 1991. Infect. Immun.59, 2567.
Landis, R.C., et al. 1991. J. Immunol.146, 128.
Schweighoffer, T., et al. 1991. Histochemistry96, 93.
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Oral - Eye Irrit. 2 - Skin Irrit. 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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