324623
Eg5 Inhibitor IV, VS-83
The Eg5 Inhibitor IV, VS-83, also referenced under CAS 909250-29-9, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.
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所有图片(1)
别名:
Eg5 Inhibitor IV, VS-83, 5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione
经验公式（希尔记法）:
C14H11FN2OS
推荐产品
质量水平
检测方案
≥99% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
ethanol: 5 mg/mL
DMSO: 50 mg/mL
运输
ambient
储存温度
−20°C
InChI
1S/C14H11FN2OS/c15-10-5-2-6-11-12(10)13(17-14(19)16-11)8-3-1-4-9(18)7-8/h1-7,13,18H,(H2,16,17,19)
InChI key
MAEYCDNDKNPNQJ-UHFFFAOYSA-N
一般描述
A cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC50 = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC50 = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells.
包装
Packaged under inert gas
警告
Toxicity: Regulatory Review (Z)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Muller, C., et al. 2007. Cancer Chemother. Pharmacol.59, 157.
Santamaria, A., et al. 2007. Mol. Biol. Cell18, 4024.
Sarli, V., et al. 2005. ChemBioChem6, 2005.
Santamaria, A., et al. 2007. Mol. Biol. Cell18, 4024.
Sarli, V., et al. 2005. ChemBioChem6, 2005.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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