324519
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1
InSolution, ≥95%, reversibly binds eukaryotic translation initiation factor 4E
别名:
InSolution eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I, eIF4F Inhibitor I, 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid
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所有图片(1)
About This Item
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质量水平
方案
≥95% (sum of two isomers, HPLC)
表单
liquid
效能
25 μM Ki
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
运输
dry ice
储存温度
−70°C
InChI
1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14+
InChI key
KFRKRECSIYXARE-HYARGMPZSA-N
一般描述
A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC50 ~25 µM). Shown to be brain permeant and reduce neuroligin protein levels, and restore L-LTP threshold and rescue autistic-like behaviours in Eif4ebp2 knockout mice.
生化/生理作用
Cell permeable: yes
Primary Target
eIF4E
eIF4E
Reversible: yes
包装
Packaged under inert gas
警告
Toxicity: Irritant (B)
外形
A 25 mM (5 mg/443 µL) solution of eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 (Cat. No. 324517)
重悬
Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
其他说明
Gkogkas, C.G., et al. 2012. Nature493, 371.
Moerke, N. J., et al. 2007. Cell128, 257.
Moerke, N. J., et al. 2007. Cell128, 257.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Reversal of memory and autism-related phenotypes in Tsc2+/- mice via inhibition of Nlgn1.
Chalkiadaki, et al.
Frontiers in Cell and Developmental Biology, 11, 1205112-1205112 (2023)
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