324411
Dynamin Inhibitor II, MiTMAB
The Dynamin Inhibitor II, MiTMAB, also referenced under CAS 1119-97-7, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.
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别名:
Dynamin Inhibitor II, MiTMAB, Tetradecyl trimethyl ammonium Bromide, Myr istyl tri methyl ammonium Bromide, TTAB
经验公式（希尔记法）:
C17H38BrN
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质量水平
检测方案
≥99% (titration)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
颜色
white
溶解性
DMSO: 10 mg/mL
water: 100 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C17H38N.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18(2,3)4;/h5-17H2,1-4H3;1H/q+1;/p-1
InChI key
CXRFDZFCGOPDTD-UHFFFAOYSA-M
一般描述
A cell-permeable cationic surfactant that reversibly inhibits dynamin GTPase activity (IC50 = 3.15 µM) by targeting the PH domain and interfering with phospholipid binding. Shown to block dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP.
包装
Packaged under inert gas
警告
Toxicity: Corrosive (L)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Quan, A., et al. 2007. Mol. Pharmacol.72, 1425.
Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett.14, 3275.
Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett.14, 3275.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT RE 2 Oral - STOT SE 3
靶器官
Gastrointestinal tract, Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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