317240
盐酸二甲双胍
≥97% (titration), solid, AMPK signaling activator, Calbiochem®
别名:
盐酸二甲双胍
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关于此项目
经验公式（希尔记法）:
C4H11N5 · xHCl
化学文摘社编号:
分子量:
129.16 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
盐酸二甲双胍, An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia.
SMILES string
Cl.N(C)(C)C(=N\C(=N\[H])\N)N
InChI
1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
InChI key
OETHQSJEHLVLGH-UHFFFAOYSA-N
description
Merck USA index - 14, 5938
assay
≥97% (titration)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white
solubility
water: 50 mg/mL
shipped in
ambient
storage temp.
10-30°C
Quality Level
Biochem/physiol Actions
主要靶标
AMP激活的蛋白激酶（AMPK）
AMP激活的蛋白激酶（AMPK）
产物不与ATP竞争。
可逆：否
细胞渗透性：否
Disclaimer
毒性：刺激性（B）
General description
一种通过降低肝脏葡萄糖输出而起作用的抗高血糖药。不会刺激胰岛素分泌，促进体重增加或引起低血糖症。据报道刺激AMP激活的蛋白激酶（AMPK），导致乙酰辅酶A羧化酶（ACC）活性降低和脂肪酸氧化诱导。
一种降低血葡萄糖水平而不刺激胰岛素分泌、促进体重增加或引起低血糖症的抗高血糖药。据报道刺激AMP激活的蛋白激酶（AMPK），导致乙酰辅酶A羧化酶（ACC）活性降低和脂肪酸氧化诱导。
Other Notes
Cleasby, M.E., et al. 2004.Diabetes53, 3258.
Klein, J., et al. 2004.J. Endocrinol.183, 299.
Zhou, G., et al. 2001.J. Clin. Invest.108, 1167.
Lin, H.Z., et al. 2000.Nat. Med.6, 998.
Klein, J., et al. 2004.J. Endocrinol.183, 299.
Zhou, G., et al. 2001.J. Clin. Invest.108, 1167.
Lin, H.Z., et al. 2000.Nat. Med.6, 998.
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多6个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Martina Poteti et al.
Cancers, 13(17) (2021-09-11)
This study was directed to characterize the role of glutamine in the modulation of the response of chronic myeloid leukemia (CML) cells to low oxygen, a main condition of hematopoietic stem cell niches of bone marrow. Cells were incubated in
Lucas M Wiggenhauser et al.
Diabetes, 69(5), 1020-1031 (2020-03-07)
Progression from the initial vascular response upon hyperglycemia to a proliferative stage with neovacularizations is the hallmark of proliferative diabetic retinopathy. Here, we report on the novel diabetic pdx1 -/- zebrafish mutant as a model for diabetic retinopathy that lacks
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