300270
PARP Inhibitor III, DPQ
The PARP Inhibitor III, DPQ, also referenced under CAS 129075-73-6, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
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别名:
PARP Inhibitor III, DPQ, 3,4-Dihydro-5[4-(1-piperindinyl)butoxy]-1(2H)-isoquinoline
经验公式（希尔记法）:
C18H26N2O2
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质量水平
检测方案
≥90% (HPLC)
形式
solid
效能
40 nM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
off-white
溶解性
DMSO: 5 mg/mL
运输
ambient
储存温度
−20°C
InChI
1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)
InChI key
RVOUDNBEIXGHJY-UHFFFAOYSA-N
一般描述
A potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.
A very potent and selective poly(ADP-ribose)polymerase (PARP) inhibitor (IC50 = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.
生化/生理作用
Cell permeable: no
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Harmful (C)
其他说明
Eliasson, M.J., et al. 1997. Nat. Med. 3, 1089.
Takahashi, K., et al. 1997. J. Cereb. Blood Flow Metabl. 17, 1137.
Suto, M.J., et al. 1991. Anticancer Drug Des. 6, 107.
Takahashi, K., et al. 1997. J. Cereb. Blood Flow Metabl. 17, 1137.
Suto, M.J., et al. 1991. Anticancer Drug Des. 6, 107.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
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