推荐产品
质量水平
描述
RTECS - NL5995050
方案
≥90% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
yellow
溶解性
water: 5 mg/mL
ethanol: soluble
methanol: soluble
荧光
λex ~359 nm
λem ~461 nm
运输
ambient
储存温度
−20°C
SMILES字符串
[Cl-].[Cl-].[nH]1c2c(cc1c3ccc(cc3)C(=N)N)ccc(c2)C(=N)N.[H+].[H+]
InChI
1S/C16H15N5.2ClH/c17-15(18)10-3-1-9(2-4-10)13-7-11-5-6-12(16(19)20)8-14(11)21-13;;/h1-8,21H,(H3,17,18)(H3,19,20);2*1H
InChI key
FPNZBYLXNYPRLR-UHFFFAOYSA-N
一般描述
DNA特异性荧光染料。优先结合富含腺嘌呤和胸苷的DNA（最大激发=359 nm，最大发射=461 nm）。可用于凋亡细胞中细胞核和核DNA的显微镜分析。可用于检测支原体。S-腺苷-L-蛋氨酸脱羧酶和二胺氧化酶的可逆抑制剂。细胞通常以1 µg/ml染色。
细胞可渗透的DNA-结合染料。优先与富含腺嘌呤和胸腺嘧啶的DNA结合。在流式细胞仪中用于测量核DNA含量或对分离的染色体进行分选。可用于正常和凋亡细胞中细胞核和核DNA的显微镜检测。可用于检测支原体。S-腺苷-L-蛋氨酸脱羧酶和二胺氧化酶的可逆抑制剂。也可以5 mg/ml mM的H2O溶液（目录号508741）提供。
生化/生理作用
主要靶标
优先与富含腺嘌呤和胸腺嘧啶的DNA结合
优先与富含腺嘌呤和胸腺嘧啶的DNA结合
产物不与ATP竞争。
可逆性：是
细胞渗透性：否
警告
毒性：标准处理（A）
重悬
复溶后，等分并冷冻长期保存（-20°C），或冷藏（4°C）短期保存。储备溶液在4°C下可稳定保存6周，在-20°C下可稳定保存6个月。
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Skin Irrit. 2 - Skin Sens. 1A - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Marta Jiménez-Martínez et al.
Cancers, 11(11) (2019-11-14)
Cell contact inhibition (CCI) is deregulated in cancer. Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. We found that dual-specificity phosphatase 10 (DUSP10) is involved in CRC. DUSP10 overexpression increased the growth of CRC cell lines and
Alexander R H Hobby et al.
American journal of physiology. Heart and circulatory physiology, 317(4), H820-H829 (2019-08-24)
Ischemic heart diseases such as myocardial infarction (MI) are the largest contributors to cardiovascular disease worldwide. The resulting cardiac cell death impairs function of the heart and can lead to heart failure and death. Reperfusion of the ischemic tissue is
Diana Sánchez-Ponce et al.
Cerebral cortex (New York, N.Y. : 1991), 22(7), 1648-1661 (2011-09-24)
The cisternal organelle that resides in the axon initial segment (AIS) of neocortical and hippocampal pyramidal cells is thought to be involved in regulating the Ca(2+) available to maintain AIS scaffolding proteins, thereby preserving normal AIS structure and function. Through
Eduardo R Zimmer et al.
Nature neuroscience, 20(3), 393-395 (2017-01-31)
Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide positron emission tomography evidence that activation of astrocytic glutamate transport via the excitatory amino acid transporter GLT-1 triggers widespread but graded glucose uptake in
Laura Rangel et al.
Scientific reports, 9(1), 1116-1116 (2019-02-06)
The primary cilium is a single non-motile protrusion of the plasma membrane of most types of mammalian cell. The structure, length and function of the primary cilium must be tightly controlled because their dysfunction is associated with disease. Caveolin 1
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