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安全信息

263200

Sigma-Aldrich

Dephostatin - CAS 151606-30-3 - Calbiochem

别名:

Dephostatin - CAS 151606-30-3 - Calbiochem, PTP Inhibitor VII

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About This Item

经验公式（希尔记法）:
C7H8N2O3
CAS号:
151606-30-3
分子量:
168.15
UNSPSC代码:
12352200

方案

≥90% (HPLC)

质量水平

100

表单

powder

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

brown

溶解性

DMSO: 5 mg/mL
chloroform: soluble

运输

ambient

储存温度

−20°C

InChI

1S/C7H8N2O3/c1-9(8-12)6-4-5(10)2-3-7(6)11/h2-4,8,12H,1H3

InChI key

FGICTAQFCLUOBH-UHFFFAOYSA-N

一般描述

This product has been discontinued.



Protein tyrosine phosphatase inhibitor. Competitively inhibits protein tyrosine phosphatase activity in membrane preparations from human neoplastic T cell line (IC50 = 7.7 µM). Reported to mobilize intracellular calcium stores. Could serve as a stable NO donor for S-nitrosylation of proteins.

Protein tyrosine phosphatase inhibitor. Competitively inhibits protein tyrosine phosphatase activity in a membrane preparation from a human neoplastic T-cell line (IC50 = 7.7 µM). Inhibits homogenous recombinant Yersinia and mammalian protein tyrosine phosphatases in a concentration and time-dependent manner.

生化/生理作用

Cell permeable: no
Primary Target
protein tyrosine phosphatase activity from human neoplastic cell line
Product competes with ATP.
Reversible: no
Target IC50: 7.7 µM against protein tyrosine phosphatase activity in membrane preparations from human neoplastic T cell line

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

制备说明

Streptomyces sp.

重悬

Following reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 3 months at -20°C.

其他说明

Lajas, A.I., et al. 2000. Mol. Cell Biochem. 205, 163.
Guo, Z., et al. 1996. Bioorganic Med. Chem. Lett.6, 573.
Watanabe, T., et al. 1995. J. Antibiot. 48, 1460.
Yu, L., et al. 1995. Bioorg. Med. Chem. Lett.9, 1003.
Imoto, M., et al. 1993. J. Antibiot.46, 1342.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

10-13 - German Storage Class 10 to 13

法规信息

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