263200
Dephostatin - CAS 151606-30-3 - Calbiochem
别名:
Dephostatin - CAS 151606-30-3 - Calbiochem, PTP Inhibitor VII
InChI key
FGICTAQFCLUOBH-UHFFFAOYSA-N
InChI
1S/C7H8N2O3/c1-9(8-12)6-4-5(10)2-3-7(6)11/h2-4,8,12H,1H3
assay
≥90% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
brown
solubility
DMSO: 5 mg/mL, chloroform: soluble
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
This product has been discontinued.
Protein tyrosine phosphatase inhibitor. Competitively inhibits protein tyrosine phosphatase activity in membrane preparations from human neoplastic T cell line (IC50 = 7.7 µM). Reported to mobilize intracellular calcium stores. Could serve as a stable NO donor for S-nitrosylation of proteins.
Protein tyrosine phosphatase inhibitor. Competitively inhibits protein tyrosine phosphatase activity in a membrane preparation from a human neoplastic T-cell line (IC50 = 7.7 µM). Inhibits homogenous recombinant Yersinia and mammalian protein tyrosine phosphatases in a concentration and time-dependent manner.
Biochem/physiol Actions
Cell permeable: no
Primary Target
protein tyrosine phosphatase activity from human neoplastic cell line
protein tyrosine phosphatase activity from human neoplastic cell line
Product competes with ATP.
Reversible: no
Target IC50: 7.7 µM against protein tyrosine phosphatase activity in membrane preparations from human neoplastic T cell line
Packaging
Packaged under inert gas
Preparation Note
Streptomyces sp.
Following reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Lajas, A.I., et al. 2000. Mol. Cell Biochem. 205, 163.
Guo, Z., et al. 1996. Bioorganic Med. Chem. Lett.6, 573.
Watanabe, T., et al. 1995. J. Antibiot. 48, 1460.
Yu, L., et al. 1995. Bioorg. Med. Chem. Lett.9, 1003.
Imoto, M., et al. 1993. J. Antibiot.46, 1342.
Guo, Z., et al. 1996. Bioorganic Med. Chem. Lett.6, 573.
Watanabe, T., et al. 1995. J. Antibiot. 48, 1460.
Yu, L., et al. 1995. Bioorg. Med. Chem. Lett.9, 1003.
Imoto, M., et al. 1993. J. Antibiot.46, 1342.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
10-13 - German Storage Class 10 to 13
法规信息
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