260960
DNA-PK Inhibitor
The DNA-PK Inhibitor, also referenced under CAS 20357-25-9, controls the biological activity of DNA-PK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
DNA-PK Inhibitor, DMNB, 4,5- Di methoxy-2- nitro benzaldehyde, DNA-Dependent Protein Kinase Inhibitor, DMNB, 4,5-Dimethoxy-2-nitrobenzaldehyde, DNA-Dependent Protein Kinase Inhibitor
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About This Item
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质量水平
方案
≥90% (GC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
bright yellow
溶解性
DMSO: 5 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
[N+](=O)([O-])c1c(cc(c(c1)OC)OC)C=O
InChI
1S/C9H9NO5/c1-14-8-3-6(5-11)7(10(12)13)4-9(8)15-2/h3-5H,1-2H3
InChI key
YWSPWKXREVSQCA-UHFFFAOYSA-N
一般描述
A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-PK (DNA-dependent protein kinase) activity (IC50 = 15 µM) and DNA-PK-mediated DSB (double strand break) DNA repair by NHEJ (non-homologous DNA-end-joining). Shown to effectively sensitize cells to killing by Cisplatin (Cat. No. 232120). Does not affect PKC or Chk2 kinase activities.
A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) activity (IC50 = 15 µM) and DNA-PK-mediated double strand break (DSB) DNA repair by non-homologous DNA-end-joining (NHEJ). Reported to effectively sensitize cells to Cisplatin (Cat. No. 232120). Does not affect the activities of PKC or Chk2.
生化/生理作用
Cell permeable: yes
Primary Target
DNA-PK activity
DNA-PK activity
Product does not compete with ATP.
Reversible: no
Target IC50: 15 µM against DNA-PK (DNA-dependent protein kinase) activity
包装
Packaged under inert gas
警告
Toxicity: Carcinogenic / Teratogenic (D)
重悬
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Willmore, E., et al. 2004. Blood,103, 4659.
Durant, S., and Karran, P. 2003. Nucleic Acids Res.31, 5501.
Durant, S., and Karran, P. 2003. Nucleic Acids Res.31, 5501.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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