251680
Dantrolene sodium salt
≥95% (HPLC), Ryanodine receptor blocker, solid
别名:
丹曲林，钠盐
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关于此项目
经验公式（希尔记法）:
C14H9N4O5 · Na
化学文摘社编号:
分子量:
336.23
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze
desiccated (hygroscopic)
desiccated (hygroscopic)
产品名称
丹曲林，钠盐, A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor.
SMILES string
[Na]N1C(=O)N(CC1=O)\N=C\c2[o]c(cc2)c3ccc(cc3)[N+](=O)[O-]
InChI
1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;
InChI key
KSRLIXGNPXAZHD-HAZZGOGXSA-M
description
Merck USA index - 14, 2816
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
orange
solubility
DMSO: 3 mg/mL
aqueous base: soluble
shipped in
ambient
storage temp.
10-30°C
Quality Level
Biochem/physiol Actions
主要靶标
Ryanodine受体
Ryanodine受体
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
Disclaimer
毒性：有害（C）
General description
从肌浆网释放的细胞内钙的细胞渗透性阻滞剂，通过与ryanodine受体结合起作用。抑制突触传递的长期抑郁和去势化。对大脑缺血有神经保护作用。
骨骼肌肉松弛药。通过与ryanodine受体结合，在激发-收缩偶联过程中阻止细胞内钙从肌浆网释放。阻止长期抑郁和去势化。
Other Notes
Wei, H., and Perry, D.C. 1996.J. Neurochem.67, 2390.
O’Mara, S.M., et al. 1995.Neuroscience68, 621.
Parness, J., and Palnitkar, S.S.1995.J. Biol. Chem.270, 18465.
Zhang, H., et al. 1995.Am. J. Physiol.269, H1874.
Hotchkiss, R.S., and Karl, I.E.1994.Proc.Natl.Acad.Sci. USA91, 3039.
Song, S.K., et al. 1994.Proc.Natl.Acad.Sci. USA91, 3039.
O’Mara, S.M., et al. 1995.Neuroscience68, 621.
Parness, J., and Palnitkar, S.S.1995.J. Biol. Chem.270, 18465.
Zhang, H., et al. 1995.Am. J. Physiol.269, H1874.
Hotchkiss, R.S., and Karl, I.E.1994.Proc.Natl.Acad.Sci. USA91, 3039.
Song, S.K., et al. 1994.Proc.Natl.Acad.Sci. USA91, 3039.
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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