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Merck
CN
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主要文件

251400

Sigma-Aldrich

D609, Potassium Salt

Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki = 5-10 µM).

别名:

D609, Potassium Salt, Tricyclodecan-9-yl-xanthogenate, K

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About This Item

经验公式（希尔记法）:
C11H15OS2 · K
CAS号:
83373-60-8
分子量:
266.46
MDL编号:
MFCD00171401
UNSPSC代码:
41106500
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

颜色

off-white

溶解性

DMSO: 25 mg/mL
water: 25 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

[K].SC(=S)OC1C2C3C(C(C2)C1)CCC3

InChI

1S/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14);

InChI key

YFUFHKMDCZBHMY-UHFFFAOYSA-N

一般描述

Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki = 5-10 µM). Does not inhibit phosphatidylinositol-specific phospholipase C, phospholipase A, or phospholipase D. Also reported to inhibit LPS-stimulated ERK activation via its inhibitory effect on PLC. Inhibits angiogenesis by preventing the synthesis of basement membrane.
Selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) (Bacillus cereus, Ki = 5-10 µM). Does not inhibit (up to 50 µM) phosphatidylinositol-specific phospholipase C, phospholipase A2, and phospholipase D. Inhibitor of the sphingomyelinase activity. Also inhibits angiogenesis by preventing the synthesis of basement membrane (BM).

生化/生理作用

Cell permeable: no
Primary Target
pc-specificphopholipase c
Product does not compete with ATP.
Reversible: no
Target Ki: 5-10 µM against phosphatidylcholine (PC)-specific phospholipase C

警告

Toxicity: Standard Handling (A)

制备说明

tissue culture media should be at neutral pH, since product is active only at or slightly below pH 7.0. The compound is inactive at pH 7.4 and above, and it is hydrolyzed below pH 6.0. HEPES buffer should not be used as it renders D609 toxic.

重悬

Material is very labile once in solution (1.5 day half-life in tissue culture medium).

其他说明

Monick, M.M., et al. 1999. J. Immunol. 162, 3005.
Lozanski, G., et al. 1997. Biochem. J.328, 271.
Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
Doppler, C., et al. 1992. AIDS Res. Human Retroviruses8, 245.
Schutze, S., et al. 1992. Cell71, 765.
Sauer, G., et al. 1990. Cancer Lett.53, 97.
Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun.162, 198.
Amtmann, E., et al. 1987. Biochem. Pharmacol.36, 1545.
Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA81, 3263.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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